Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat Cutaneous Wound

Table 1

Histopathological evaluation of wound healing process in different treatment groups.

Groups	Wound healing process
	S	U	Ed	PMC	MNC	FP	RE	CD
Day 7
Nontreated	++	++	++/+	+++	+	+/−	−	−
Vehicle control	+++	++/+	++	+++/++	+	+	−	−/+
CvME (2.5%)	+	−	−	++	++/+++	++	+	++
Gentamicin sulfate (0.01%)	+	−	−	++	++	++	+	++
Day 15
Nontreated	+	+	−	++	+++	++	+	++
Vehicle control	+	+	−	++	+++	++	++	++
CvME (2.5%)	−	−	−	−/+	+	+++	+++	+++
Gentamicin sulfate (0.01%)	−	−	−	−/+	+	+++	+++	+++

HE and MT staining were scored as mild (+), moderate (++), and severe (+++) for epidermal and/or dermal remodeling. S: scab; U: ulcer; Ed: edema; PMC: polymorphonuclear cells; MNC: mononuclear cells; FP: fibroblast proliferation; CD: collagen deposition; RE: reepithelialization; CvME: C. viscosa methanol extract.