Microbleeds in Late-Life Depression: Comparison of Early- and Late-Onset Depression

Table 1

Demographic, neuropsychosocial, and radiological characteristics of all subjects.

	Control; (𝑛=85)	EOD; (𝑛=57)	𝑃; (versus control)	POD; (𝑛=54)	𝑃; (versus control)	LOD; (𝑛=84)	𝑃; (versus control)
Age, years	72.25±5.87	71.84±4.95	0.669	73.06±5.61	0.422	73.23±4.78	0.236
Female	41 (48.2%)	37 (64.9%)	0.050	35 (64.8%)	0.056	53 (63.1%)	0.052
Education, years	4.25±3.65	4.21±4.18	0.956	3.56±2.82	0.238	3.99±3.64	0.645
Hypertension	52 (61.2%)	37 (64.9%)	0.652	33 (61.1%)	0.994	59 (70.2%)	0.215
Diabetes	24 (28.2%)	12 (21.1%)	0.335	16 (29.6%)	0.860	29 (34.5%)	0.378
MMSE	25.64±2.68	25.33±2.86	0.522	24.67±2.64	0.038	24.39±2.42	0.002
LSNS	36.11±4.80	32.88±4.32	0.000	33.46±4.26	0.001	34.58±5.23	0.050
SLE	0.74±0.79	1.91±1.20	0.000	1.69±1.18	0.000	0.82±0.79	0.511
GDS	2.36±1.50	8.96±1.77	0.000	9.09±1.73	0.000	8.62±1.96	0.000
Grade of PWMH	0.94±0.92	1.14±0.95	0.214	1.30±1.06	0.038	1.56±0.97	0.000
Grade of DWMH	0.86±0.79	0.96±0.82	0.441	1.06±0.92	0.182	1.54±0.94	0.000
Prevalence of SBI	28 (32.9%)	17 (29.8%)	0.696	25 (46.3%)	0.114	47 (56.0%)	0.003
Prevalence of microbleeds in
Any region	20 (23.5%)	13 (22.8%)	0.920	15 (27.8%)	0.574	35 (41.7%)	0.012
Left hemisphere	10 (11.8%)	7 (12.3%)	0.926	12 (22.2%)	0.100	28 (33.3%)	0.001
Right hemisphere	14 (16.5%)	10 (17.5%)	0.721	8 (14.8%)	0.794	20 (23.8)	0.234
Infratentorial	9 (10.6%)	5 (8.8%)	0.722	7 (13.0%)	0.669	13 (15.5%)	0.345
Lobar	10 (11.8%)	8 (14.0%)	0.690	11 (20.4%)	0.167	27 (32.1%)	0.001
Deep	14 (16.5%)	11 (19.3%)	0.665	9 (16.7%)	0.976	22 (26.2%)	0.123

EOD: early-onset depression; POD: presenile-onset depression; LOD: late-onset depression; MMSE: minimental state examination; LSNS: Lubben Social Network Scale; SLE: Scale of Life Events; GDS: Geriatric Depression Scale; PWMH: periventricular white matter hyperintensities; DWMH: deep white matter hyperintensities; SBI: silent brain infarction.