Research Article

Dehydroabietic Acid Derivative QC2 Induces Oncosis in Hepatocellular Carcinoma Cells

Figure 2

QC2 induced cell death in HCC and human hepatocytes. (a) QC2 exerted cytotoxicity in four HCC cell lines as well as in human hepatocytes; the IC50 values were 0.37 μg/mL, 1.17 μg/mL, 3 μg/mL, 2.67 μg/mL, and 4.22 μg/mL, respectively. (b) QC2 induced cell death in SMMC-7721 cells was testified by flow cytometry. (c) QC2 dose-dependently induced morphological changes in SMMC-7721 cells.