Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice

Figure 1

Thermoregulatory deficits and lethality by WBH. (a) Thermoregulatory dysfunction (or animals become hypothermia when exposing them to room temperature, 26°C) caused by whole body heating (WBH; 41.2°C for 1 h). Data are expressed as means ± S.E.M. of 12 mice per group. *At time “0” h after WBH (or immediately after the termination of WBH), heated mice treated with vehicle (WBH + vehicle; “○”) or heated mice treated with CD34⁺ cells (WBH + CD34⁺ cells; “△”) had significantly higher rectal temperature (~42.5°C) than those of non-WBH mice treated with vehicle (non-WBH + vehicle; “●”). In contrast, at time “4” h, “8” h, “12” h, or “16” h after WBH, (WBH + vehicle) group had significantly lower rectal temperature (Tco; ~35°C–~32.5°C) than those of (non-WBH + vehicle) group. ⁺At time “4” h, “8” h, “12” h, or “16” h after WBH, (WBH + CD34⁺ cells) group had significantly higher rectal temperature than those of (WBH + vehicle) group (𝑃<0.01). (b) Lethality (or decreased percentage survival) caused by WBH. *𝑃<0.01, (non-WBH + vehicle) mice versus (WBH + vehicle) mice. ⁺𝑃<0.01, (WBH + CD34⁺ cells) group versus (WBH + vehicle) group.

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