Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice

Table 3

Effect of heat exposure on hypothalamic levels of malondialdehyde (MDA), oxidative-form glutathione (GSSG)/reduced-form glutathione (GSH), glutathione peroxidase (GP_𝑥), glutathione reductase (GR), nitric oxide metabolites (NO_𝑥⁻), and 2,3-dihydroxy benzoic acid (2,3-DHBA) in different groups of mice.

Treatment groups	MAD; (nmol/mg protein)	GSSG/GSH	GP; (mU/mg protein)	GR; (mu/mg protein)	NO𝑥^− (μM)	2,3-DHBA; (percentage of baseline)
(1) Non-WBH mice	5±2	0.45±0.14	314±36	175±16	19±2	100±6
(2) Non-WBH mice treated with; CD34^+ cells	4±2	0.42±0.16	302±33	169±17	17±3	99±5
(3) WBH mice treated with; vehicle saline	12±2^a	2.43±0.38^a	83±17^a	81±13^a	115±12^a	188±10^a
(4) WBH mice treated with; CD34^+ cells	4±2^b	0.42±0.15^b	257±28^b	166±15^b	21±4	103±5^b

Samples were measured 4 hours after whole body heating (WBH; 41.2°C for 1 hour) or the equivalent period for non-WBH. ^acompared with non-WBH group (𝑃<0.01); ^bcompared with group 2 (𝑃<0.05). Data are means ± S.E.M. of 12 mice per group.