Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia

Table 2

Oxidative stress parameters and cytogenetic subgroups in CLL patients.

	del(13q14); 𝑛 = 18; Mean ± SD	Trisomy 12; 𝑛 = 8; Mean ± SD	del(11q22); 𝑛 = 6; Mean ± SD	del(17p13); 𝑛 = 6; Mean ± SD	Normal FISH; 𝑛 = 17; Mean ± SD	𝑃 value^a
Lymphocytes 8-oxo-dG/10^6 dG	39.40 ± 15.69	44.65 ± 12.26	43.58 ± 16.82	54.46 ± 21.66	57.17 ± 18.45	0.034
Urinary 8-oxo-dG (nmol/mmol creatinine)	19.70 ± 15.32	22.87 ± 15.13	27.31 ± 15.03	12.22 ± 4.50	18.76 ± 11.60	0.676
Glutathione (nmol/mg prot.)	28.28 ± 5.08	26.15 ± 5.75	35.48 ± 9.00	26.72 ± 6.35	28.30 ± 8.09	0.118
MDA (nmol/mg prot.)	1.14 ± 0.61	1.04 ± 0.74	2.09 ± 1.73	2.08 ± 0.78	1.48 ± 0.78	0.050

8-oxo-dG: 8-oxo-2-deoxyguanosine; MDA: malondialdehyde; SD: standard deviation.
^aTo determine whether there were any global significant differences between the means of cytogenetic subgroups, we performed the one-way analysis of variance (ANOVA) test.