Research Article

Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology

Table 3

Summary of results of regression analysis for responses and analysis of variance for particle size, EE, and DL.

ParametersDFSSMS value SDCoeff. of variance %

Mean particle size
Model5 26902.549.040.0045 significant0.987923.426.91
Residual31645.67548.56
Total8

%Entrapment efficiency
Model5149.3329.8711.560.0356 significant0.95071.611.81
Residual37.752.58
Total8157.08

%Drug loading
Model5168.8933.7861.660.0032 significant0.99040.743.21
Residual31.640.55
Total8170.53