Formulation Optimization of Erythromycin Solid Lipid Nanocarrier Using Response Surface Methodology

Table 4

Comparison of the observed and predicted values in the SLN prepared under predicted optimum conditions.

S. number	Response variables	Predicted optimum range		Predicted value	Observed value	Bias %
		𝑋1 (mg/mL)	𝑋2
1	Mean particle size (nm)	15	1.07 : 1	144.59	153.21	−5.96
2	%EE	15	1.07 : 1	90.21	88.40	2.00
3	%DL	15	1.07 : 1	29.78	29.46	1.07
4	PDI	15	1.07 : 1	—	0.026	—
5	ZP	15	1.07 : 1	—	−15.18	—