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BioMed Research International
Volume 2014, Article ID 691540, 9 pages
Research Article

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

1Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, China
2Department of Cardiovascular Medicine, China-Japan Union Hospital of Jilin University, Jilin 132000, China
3Department of Pediatrics, the First Affiliated Hospital of Jilin University, Jilin 132000, China

Received 4 July 2014; Revised 26 July 2014; Accepted 12 August 2014; Published 16 October 2014

Academic Editor: Konstantinos Kantartzis

Copyright © 2014 Ze-Lin Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis. Method. Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model. Results. Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD = 1.36, 95%CI: 0.37–2.36, ). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD = 1.73, 95%CI: 0.20–3.26, ), but not in Asians (SMD = 1.04, 95%CI: −0.33–2.40, ). Conclusion. The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.