Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals

Table 1

Effect of metformin, diazepam, or their combination on plasma glucose level during OGTT in cooccurring T2DM and RS exposed rats.

Groups	Plasma glucose level (mg/dL)
	0 min	30 min	60 min	120 min
Control	74.3±1.3	143.6±1.8	157.3±3.9	111.5±3.8
DMS	512.4±12.9^a	969.2±34.3^a	1202.8±26.0^a	1192.7±21.8^a
DMS + MET	420.3±6.6^a,b	609.6±25.5^a,b	690.0±23.5^a,b	555.6±24.2^a,b
DMS + DZ	499.0±9.7^a,c	941.9±23.0^a,c	1156.6±16.2^a,c	1188.5±29.0^a,c
DMS + MET + DZ	206.9±4.3^a,b,c,d	445.5±24.0^a,b,c,d	448.7±26.0^a,b,c,d	426.3±9.0^a,b,c,d

All values are mean ± SEM (𝑛=6). ^a𝑃<0.05 compared to control, ^b𝑃<0.05 compared to DMS, ^c𝑃<0.05 compared to DMS + MET, and ^d𝑃<0.05 compared to DMS + DZ (repeated measures of two-way ANOVA followed by Bonferroni post hoc test).