Amelioration of Paracetamol-Induced Hepatotoxicity in Rat by the Administration of Methanol Extract of Muntingia calabura L. Leaves

Table 2

Histopathological scoring of the tissue of PCM-induced hepatic injury rats after pretreatment with MEMC.

Treatment	Dose (mg/kg)	Steatosis	Necrosis	Inflammation	Haemorrhage
Normal	−	−	−	−	−
10% DMSO + PCM		−	+++	++	++
NAC + PCM	50	−	+	+	−
MEMC + PCM	50	−	++	+	+
	250	−	+	+	−
	500	−	+	+	−

The severity of various features of hepatic injury was evaluated based on those following scoring schemes: − normal, + mild effect, ++ moderate effect, and +++ severe effect.