Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production
Figure 4
Bax translocation to mitochondria from cytoplasm after being treated with ebselen is determined by Western blot. (a) Ebselen decrased Bax level in cytoplasm in a concentration and time dependent manner. (b) Mitochondria Bax level increased and cytoplasmic Bax level decreased in MM cells treated with ebselen 40 μM for 4 hours. (c) The decreasing of cytoplasmic Bax level can be recovered partially by 15 mM NAC.
