Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production
Figure 6
Ebselen induced mitochondrial cytochrome C release from the mitochondria to cytosol. A representative immunoblot of MM cell cultures in presence or absence of ebselen showing levels of cytochrome C in cytosolic and mitochondrial extracts. Cells were treated for 4 h with ebselen. COX-IV and β-actin protein levels were used as internal reference of mitochondrial and cytosol, respectively. The record shown is representative of three experiments.
