Table 1: Characteristics of included randomized controlled trials.

First author, year (country)Number of study sitesSample sizePopulation, %Mean age, (years)Diabetic, %Initial glucose, mg/dLGlucose goal, mg/dLGlucose achieved, mean (SD), mg/dL

Cappi 2012 (Brazil) [14]163Severe sepsis
Septic shock
5324 IIT 144 [97–182]* Control 141 [101–160]*IIT 80–110
Control 140–180
IIT 99 (18) Control 155 (39.6)

COIITSS 2010 (France) [16]11509Septic shock 10064NAIIT 216 (NA) Control 204 (NA) IIT 80–110
Control 180–200
IIT 120–140
Control 140–160

Savioli 2009 (Italy) [12]390Severe sepsis 65.6
Septic shock 34.4
6113.3IIT 175 (101) Control 160 (74)IIT 80–110
Control 180–200
IIT 112 (23) Control 159 (31)

Iapichino 2008 (Italy) [11]372Severe sepsis 19.4
Septic shock 80.6
62.317IIT 137 (45) Control 151.7 (36.6)IIT 80–110
Control 180–200
IIT 110 (17) Control 163 (29)

Brunkhorst 2008 (Germany) [10]18537Septic shock 10064.630IIT 130 [108–167]* Control 138 [111–184]*IIT 80–110
Control 180–200
IIT 112 (NA) Control 151 (NA)

Ellger 2008 (Belgium) [25]1950Severe sepsis 51.4
Septic shock 48.6
6214IIT 163 (73) Control 161 (70)IIT 80–110
Control 180–200
IIT 106 (26) Control 150 (30)

Yu 2005 (China) [13]155Sepsis46NAIIT 153 (61) Control 151 (65)IIT 80–110
Control 180–200
IIT 103 (22) Control 198 (29)

Dong 2009 (China) [27]127Septic shock 100440IIT157 (45) Control 159 (39.6)IIT 74–110
Control 112–150
IIT 108 (27) Control 148 (34)

NICE-SUGAR 2009 (Australia and New Zealand—Canada) [17] 421299Severe sepsis
Septic shock
60.220.1IIT 146 (52.3) Control 144 (49.1)IIT 81–108
Control 180 or less
IIT 115 (18) Control 144 (23)

Arabi 2008 (Saudi Arabia) [24]1122Severe sepsis
Septic shock
52.440.0IIT 195 (75) Control 211 (81) IIT 80–110
Control 180–200
IIT 115 (18) Control 171 (34)

Zhang 2008 (China) [26] 122Sepsis66.327.5IIT 165 (55) Control 200 (100)IIT 80–110
Control 130–150
IIT 119 (7.6) Control 141 (7.9)

Jin 2009# (China) [23]14356Severe sepsis
Septic shock
65.7NAIIT NA
Control NA
IIT 80–110; 120–150
Control 180–200
IIT 80–110: 99 (31);
120–150: 133 (34)
Control 189 (40)

IIT: intensive insulin therapy; NA: not available from article or author.
Median (interquartile range).
Abstract only.