Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model
Figure 1
Four micrographs taken from the cortex of kidney in control (a), CAPE (b), Amphotericin B (c), and Amphotericin B + CAPE (d) groups. Control rats show no abnormality (a) and CAPE group had similar findings with the control group (b). Necrotic areas located in the cortex, dilatation-degeneration of the proximal and distal tubules, and proximal and distal epithelial cells which are abundant hyperchromatic nuclei are clearly observed in the rat kidneys given amphotericin B (c). Although CAPE treatment reduced the severity of renal damage, it was not able to protect completely the histopathological damages (d).