Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique

Table 7

Kinetics study of drug release.

Formula code	Zero-order		First-order		Higuchi model		Korsmeyer-Pappas’ model
	𝑅^2	𝑘	𝑅^2	𝑘	𝑅^2	𝑘	𝑅^2	𝑛
F2	0.919	0.221	0.980	0.374	0.995	0.053	0.996	1.840
F2 PM	0.929	0.626	0.064	0.016	0.971	0.126	0.975	0.809
F3	0.940	0.285	0.979	0.423	0.993	0.060	0.921	0.557
F3 PM	0.983	0.812	0.107	0.025	0.968	0.151	0.978	0.976
F4	0.962	0.321	0.982	0.416	0.996	0.059	0.990	1.320
F4 PM	0.927	0.115	0.416	0.077	0.965	0.216	0.978	0.964
F5	0.931	0.244	0.974	0.378	0.989	0.054	0.990	0.165
F5 PM	0.966	0.713	0.331	0.063	0.973	0.139	0.974	0.780
F6	0.940	0.258	0.977	0.381	0.993	0.054	0.989	1.560
F6 PM	0.966	0.713	0.157	0.038	0.979	0.180	0.959	0.937

F: matrix tablet prepared from liquisolid system.
F PM: matrix tablet prepared from physical mixture.