Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease

Table 1

Description of the polymorphisms included in this study.

Gene symbols; (HGNC)		Gene name	Polymorphism (SNP)	Location	SNP ID
1	2	3	4	5	6
1	GPX1	Glutathione peroxidase 1	C>T (P198L)	exon 1	rs1050450
2	GPX2	Glutathione peroxidase 2 (gastrointestinal)	G>A (R146C)	exon 2	rs17880492
3	GPX3	Glutathione peroxidase 3 (plasma)	249G>A	3′ UTR	rs2070593
4	GPX4	Glutathione peroxidase 4 (phospholipid hydroperoxidase)	C718T	3′ UTR	rs713041
5	GSR	Glutathione reductase	T>C (30546636T>C)	intron 9	rs2551715
6	SOD2	Superoxide dismutase 2, mitochondrial	A16V	exon 2	rs4880
7	SOD3	Superoxide dismutase 3, extracellular	A40T (A58T)	exon 3	rs2536512
8	CAT	Catalase; —//—	−21A>T (−89A>T)	5′ UTR	rs7943316
9	CAT		−262C>T (4760C>T)	5′ UTR	rs1001179
10	GCLM	Glutamate-cysteine ligase, modifier subunit	−588C>T (4704C>T)	5′ UTR	rs41303970
11	GCLM		−23G>T	5′UTR	rs743119
12	NQO1	NAD(P)H dehydrogenase, quinone 1; —//—	P187S	exon 6	rs1800566
13	NQO1		R139W	exon 4	rs4986998
14	CYBA	Cytochrome b-245, alpha polypeptide; —//—; —//—	242C>T (Y72H)	exon 4	rs4673
15	CYBA		640A>G (24G>A)	3′ UTR	rs1049255
16	CYBA		−930A>G	5′ UTR	rs9932581
17	MPO	Myeloperoxidase	−463G>A (4535G>A)	5′ UTR	rs2333227
18	PRDX1	Peroxiredoxin 1	C>A	5′ UTR	rs17522918
19	TXNRD1	Thioredoxin reductase 1	C>G	5′ UTR	rs1128446
20	FMO3	Flavin-containing monooxygenase 3	E158K	exon 4	rs2266782
21	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	I462V	exon 7	rs1048943
22	CYP1A1		T6235C	3′ UTR	rs4646903
23	CYP2E1	Cytochrome P450, family 2, subfamily; E, polypeptide 1; —//—; —//—	−1293G>C	5′ UTR	rs3813867
24	CYP2E1		−1053C>T	5′ UTR	rs2031920
25	CYP2E1		7632T>A	intron 6	rs6413432
26	CYP2E1		9896C>G	intron 7	rs2070676
27	EPHX1	Epoxide hydrolase 1, microsomal (xenobiotic)	Y113H (337T>C)	exon 3	rs1051740
28	EPHX1		H139R (416A>G)	exon 4	rs2234922
29	PON1	Paraoxonase 1	Q192R	exon 6	rs662
30	PON2	Paraoxonase 2	C311S	exon 9	rs7493
31	GSTM1	Glutathione S-transferase mu 1	Expressor/deletion	exons 6-7	—
32	GSTT1	Glutathione S-transferase theta 1	Expressor/deletion	exon 4	—
33	GSTP1	Glutathione S-transferase pi 1; —//—	I105V	exon 5	rs1695
34	GSTP1		A114V	exon 6	rs1138272
35	TNF	Tumor necrosis factor	−308G>A	5′ UTR	rs1800629
36	IL1B	Interleukin 1, beta	−511C>T	5′ UTR	rs16944
37	IL3	Interleukin 3 (colony-stimulating factor, multiple)	S27P	exon 1	rs40401
38	IL3		−15C>T	5′ UTR	rs31480
39	IL5	Interleukin 5 (colony-stimulating factor, eosinophil)	C-703T	5′ UTR	rs2069812
40	CSF2RB (IL5RB)	Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	G1972A	exon 5	rs131840
41	IL9	Interleukin 9	T113M	exon 5	rs2069885
42	IL13	Interleukin 13	−1111C>T	5′ UTR	rs1800925
43	SCGB1A1 (CC16)	Secretoglobin, family 1A, member 1 (uteroglobin)	A38G	exon 1	rs11549442
44	SERPINA1	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	E288V	exon 3	rs17580
45	SERPINA1		D365N	exon 5	rs143370956
46	SERPINA1		1331G>A	3′ UTR	rs11568814