Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
Table 2
Allele frequencies of genes investigated in the present study.
Gene
Polymorphism
Alleles
Allele frequency
Controls
Asthma, entire group
Allergic asthma
Nonallergic asthma
1
2
3
4
5
6
7
GPX2
G>A (rs17880492)
G
0.991
0.981
0.987
0.964
A
0.009
0.019
0.013
0.036
GPX3
G>A (rs2070593)
G
0.703
0.726
0.734
0.696
A
0.297
0.274
0.266
0.304
GPX4
C718T (rs713041)
718T
0.402
0.391
0.407
0.348
718C
0.598
0.609
0.593
0.652
GSR
T>C (rs2551715)
T
0.442
0.398
0.362
0.491
C
0.558
0.602
0.638*
0.509
SOD2
A16V (rs4880)
16A
0.528
0.486
0.481
0.509
16V
0.472
0.514
0.519
0.491
SOD3
A40T (rs2536512)
40A
0.322
0.321
0.324
0.295
40T
0.678
0.679
0.676
0.705
PRDX1
C>A (rs17522918)
C
0.923
0.937
0.942
0.920
A
0.077
0.063
0.058
0.080
TXNRD1
C>G (rs1128446)
C
0.808
0.821
0.808
0.857
G
0.192
0.179
0.192
0.143
FMO3
E158K (rs2266782)
158E
0.549
0.537
0.529
0.571
158K
0.451
0.463
0.471
0.429
TNF
−308G>A (rs1800629)
−308G
0.888
0.872
0.875
0.866
−308A
0.112
0.128
0.125
0.134
IL1B
−511C>T (rs16944)
−511C
0.710
0.664
0.670
0.652
−511T
0.290
0.336
0.330
0.348
IL3
S27P (rs40401)
27S
0.738
0.685
0.686
0.688
27P
0.262
0.315
0.314
0.313
IL3
−15C>T (rs31480)
−15C
0.741
0.683
0.686
0.688
−15T
0.259
0.317
0.314
0.313
IL5
C-703T (rs2069812)
−703C
0.673
0.778
0.788
0.732
−703T
0.327
0.222*
0.212*
0.268
IL5RB (CSF2RB)
G1972A (rs131840)
1972G
0.831
0.866
0.872
0.848
1972A
0.169
0.134
0.128
0.152
IL9
T113M (rs2069885)
113T
0.820
0.863
0.856
0.893
113M
0.180
0.137
0.144
0.107
IL13
−1111C>T (rs1800925)
−1111C
0.729
0.693
0.692
0.714
−1111T
0.271
0.307
0.308
0.286
CC16 (SCGB1A1)
A38G (rs11549442)
38A
0.347
0.367
0.372
0.366
38G
0.653
0.633
0.628
0.634
SERPINA1
E288V (rs17580)
288E
0.993
0.991
0.990
0.991
288V
0.007
0.009
0.010
0.009
SERPINA1
D365N (rs143370956)
365D
0.991
0.995
0.997
0.991
365N
0.009
0.005
0.003
0.009
SERPINA1
1331G>A (rs11568814)
1331G
0.937
0.933
0.926
0.946
1331A
0.063
0.067
0.074
0.054
a difference in minor allele frequency between asthmatics and controls.
