Research Article
Impact of Immunogenetic IL28B Polymorphism on Natural Outcome of HCV Infection
Table 3
IL28B rs12979860 variant frequencies in 178 blood donors and 1097 patients with HCV infection and different outcomes. Italian case series.
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Blood donors
(HCV neg.) |
Spontaneous clearance of HCV | HCV patients |
HCV patients total | | Chronic HCV | Hepatocellular carcinoma | Mixed cryoglobulinemia S. | Non-Hodgkin’s lymphoma | | | Number (%) | Number (%) | Number (%) | Number (%) | Number (%) | Number (%) | Number (%) |
| | IL28B genotype | | | | | | | | | CC | 75 (42.1) | 37 (78.7) | 197 (36.7) | 28 (29.5) | 144 (40.9) | 22 (32.9) | 391 (37.2) | | CT | 89 (50.0) | 9 (19.2) | 271 (50.6) | 49 (51.6) | 155 (44.0) | 37 (55.2) | 512 (48.8) | | TT | 14 (7.9) | 1 (2.1) | 68 (12.7) | 18 (18.9) | 53 (15.1) | 8 (11.9) | 147 (14.0) | | Total | 178 (100.0) | 47 (100.0) | 536 (100.0) | 95 (100.0) | 352 (100.0) | 67 (100.0) | 1050 (100.0) | | ( value)a | — | Ref. | 31.9 (<0.001) | 31.4 (<0.001) | 24.4 (<0.001) | 23.5 (<0.001) | 32.8 (<0.001) |
| | IL28B dominant model | | | | | | | | | CC | 75 (42.1) | 37 (78.7) | 197 (36.7) | 28 (29.5) | 144 (40.9) | 22 (32.9) | 391 (37.2) | | CT + TT | 103 (57.9) | 10 (21.3) | 339 (63.3) | 67 (70.5) | 208 (59.1) | 45 (67.1) | 659 (62.8) | | Total | 178 (100.0) | 47 (100.0) | 536 (100.0) | 95 (100.0) | 352 (100.0) | 67 (100.0) | 1050 (100.0) | | ( value)a | — | Ref. | 31.7 (<0.001) | 30.7 (<0.001) | 23.9 (<0.001) | 23.3 (<0.001) | 32.5 (<0.001) |
| | IL28B allele | | | | | | | | | C | 239 (67.1) | 83 (88.3) | 665 (62.0) | 105 (55.3) | 443 (62.9) | 81 (60.4) | 1294 (61.2) | | T | 117 (32.9) | 11 (11.7) | 407 (48.0) | 85 (44.7) | 261 (37.1) | 53 (39.6) | 806 (38.8) | | Total | 356 (100.0) | 94 (100.0) | 1072 (100.0) | 190 (100.0) | 704 (100.0) | 134 (100.0) | 2100 (100.0) | | ( value)a | — | Ref. | 25.9 (<0.001) | 30.7 (<0.001) | 23.8 (<0.001) | 21.2 (<0.001) | 27.4 (<0.001) |
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Pearson’s chi-square with spontaneous clearance of HCV as reference group.
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