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BioMed Research International
Volume 2014, Article ID 710945, 8 pages
http://dx.doi.org/10.1155/2014/710945
Research Article

Cardiovascular Risk Factor Analysis in Patients with a Recent Clinical Fracture at the Fracture Liaison Service

1Department of Internal Medicine, VieCuri Medical Centre, P.O. Box 1926, 5900 BX Venlo, The Netherlands
2Department of Internal Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre (MUMC), P.O. Box 616, 6200 MD Maastricht, The Netherlands
3Department of Internal Medicine, Subdivision Rheumatology, CAPHRI, Maastricht University Medical Centre (MUMC), P.O. Box 616, 6200 MD Maastricht, The Netherlands
4Biomedical Research Centre, Hasselt University, Agoralaan, Gebouw D, 3590 Diepenbeek, Belgium
5Department of Surgery, VieCuri Medical Centre, P.O. Box 1926, 5900 BX Venlo, The Netherlands
6Department of Orthopaedic Surgery, VieCuri Medical Centre, P.O. Box 1926, 5900 BX Venlo, The Netherlands

Received 18 June 2014; Accepted 29 July 2014; Published 27 August 2014

Academic Editor: Alice Santos-Silva

Copyright © 2014 Caroline E. Wyers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with a low bone mineral density have an increased risk of cardiovascular diseases (CVD) and venous thromboembolic events (VTE). The aim of our retrospective chart review was to investigate the prevalence of CVD, VTE, hypertension (HT), and diabetes mellitus type 2 (DM2) in patients with a recent clinical fracture visiting the Fracture Liaison Service (FLS). Out of 3057 patients aged 50–90 years, 1359 consecutive patients, who agreed and were able to visit the FLS for fracture risk evaluation, were included (71.7% women; mean age 65.2 yrs). Based on medical history, 29.9% had a history of CVD (13.7%), VTE (1.7%), HT (14.9%), and DM2 (7.1%) or a combination. Their prevalence increased with age (21% in patients aged 50–59 years to 48% in patients aged >80 years) and was higher in men than in women (36% versus 27%), but independent of bone mineral density and fracture type. Careful evaluation of medical history with respect to these risk factors should be performed in patients with a recent clinical fracture before starting treatment with medications that increase the risk of VTE or cardiovascular events, such as raloxifene, strontium ranelate, or NSAIDs.