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BioMed Research International
Volume 2014, Article ID 717318, 8 pages
http://dx.doi.org/10.1155/2014/717318
Research Article

Serum and Urinary NGAL in Septic Newborns

1Department of Neonatal Intensive Care, Upper Silesian Centre of Child’s Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland
2Department of Pathophysiology, Medical University of Silesia, Ul. Medykow 18, 40-752 Katowice, Poland

Received 30 April 2013; Revised 29 September 2013; Accepted 25 October 2013; Published 21 January 2014

Academic Editor: Marlies Ostermann

Copyright © 2014 Mike Smertka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status.