Serum and Urinary NGAL in Septic Newborns

Table 2

The values of creatinine, cystatin C, and NGAL in three subgroups of newborns on the following time-points. Mean value, 95% CI, and statistical significance of differences between the subgroups A, B, and C (𝑈 Mann-Whitney test) are presented, together with intragroup changes (ANOVA test).

	Control group; (𝑁=29) (A)	Sepsis; (𝑁=51) (B)	Sever sepsis; (𝑁=22) (C)	Statistical significance
Creatinine (mg/dL)
Initial	0.81 (0.70–0.91)	0.76 (0.67–0.85)	0.86 (0.70–1.02)	NS
After 24 hours	0.74 (0.63–0.84)	0.74 (0.65–0.83)	0.87 (0.71–1.03)	NS
After 48 hours	0.67 (0.59–0.74)	0.63 (0.57–0.69)	0.89 (0.60–1.19)	NS
ANOVA	𝑃<0.001	𝑃<0.001	NS
Cystatin C (mg/L)
Initial	1.82 (1.68–1.96)	1.79 (1.57–2.01)	1.71 (1.40–2.01)	NS
After 24 hours	1.95 (1.64–2.26)	1.54 (1.42–1.67)	1.55 (1.22–1.89)	NS
After 48 hours	1.75 (1.59–1.90)	1.53 (1.42–1.64)	1.67 (1.32–2.02)	NS
ANOVA	NS	NS	NS
sNGAL (ng/dL)
Initial	109.9 (69.5–150.3)	203.8 (156.8–251.5)	296.5 (193.1–400.0)	C versus A 𝑃<0.001; B versus A 𝑃<0.001
After 24 hours	84.2 (53.8–114.6)	221.9 (160.2–283.6)	276.0 (178.2–373.8)	C versus A 𝑃<0.001; B versus A 𝑃<0.001
After 48 hours	83.8 (49.8–117.7)	151.8 (112.7–191.4)	202.5 (98.2–306.7)	C versus A 𝑃<0.001; B versus A 𝑃<0.05
ANOVA	NS	𝑃<0.001	𝑃=0.01
uNGAL (ng/dL)
Initial	40.4 (13.8–67.1)	157.5 (101.3–213.8)	286.6 (137.0–436.2)	C versus A 𝑃<0.001; B versus A 𝑃<0.001
After 24 hours	41.2 (5.8–76.5)	137.0 (85.0–189.0)	106.8 (57.3–156.3)	C versus A 𝑃<0.001; B versus A 𝑃<0.001
After 48 hours	46.4 (25.8–67.0)	106.8 (57.3–156.3)	177.4 (66.8–287.8)	C versus A 𝑃<0.01; B versus A 𝑃<0.05
ANOVA	NS	NS	NS