Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease
Table 2
Results of cluster analysis of 1429 transcripts by DAVID.
Cluster
Gene ontology terms and annotations
Count*
Enrichment score**
value
FDR***
Processes related to functioning of immune system
Immune system process
GO:0002376
100
6.21
Defense response
GO:0006952
68
3.72
Response to cytokine stimulus
GO:0034097
17
2.92
Positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
19
2.82
Processes related to cellular transport
Endosome
GO:0005768
41
4.12
Vesicle-mediated transport
GO:0016192
63
3.52
Protein kinase cascade (intracellular signal transduction)
GO:0035556
48
3.04
Membrane-enclosed lumen
GO:0031974
141
2.3
Intracellular transport
GO:0046907
66
1.55
Endoplasmic reticulum lumen
GO:0005788
14
1.50
Other processes
Alternative splicing
GO:0008380
514
9.31
Lysosome
GO:0005764
21
2.64
Regulation of catalytic activity
GO:0050790
77
2.23
Regulation of molecular function
GO:0065009
85
2.23
Regulation of catalytic activity
GO:0050790
77
1.49
Count is number of genes in a cluster.
**Enrichment score ranks the biological significance of gene groups based on overall EASE scores of all enriched annotation terms.
***False-discovery rate (FDR) or the correction of values using the Benjamini-Hochberg method.
