Finding Semirigid Domains in Biomolecules by Clustering Pair-Distance Variations

Figure 1

Alignment of amino acid sequences of HLA-B^∗44:02, HLA-B^∗44:03, and HLA-B^∗44:05 (downloaded from IMGT/HLA database [19]). HLA-B^∗44:05 was used as a template for homology modeling, because a three-dimensional structure of this MHC in complex with ABCD3 peptide and LC13 TCR was available. Sequence alignment was done with CLC bio’s CLC sequence viewer. Note that sequence numbering from PDB (PDB numbering) and IMGT/HLA database (HLA numbering) differ.