Treatment of Malignant Gliomas in Elderly Patients: A Concise Overview of the Literature

Table 1

Data on outcome in elderly patients affected by glioblastoma.

Author	Therapy	PTS	KPS	Median age (years)	PFS (ms)	OS (ms)
Uzuka et al. [23]	RT or CT	79	60	78	6.8	9.8
Minniti et al. [19]	RT (60 Gy) + TMZ	32	80	74	7	10.6
Malmstrom et al. [25]	RT (34 Gy) versus RT (60 Gy) versus TMZ	342	60–100	70	NA	7.5 versus 6 versus 8.3
Lombardi et al. [38]	RT (60 Gy) + TMZ versus TMZ alone	60	80	70	12.7 versus 9.5	12.4 versus 13.7
Wick et al. [26]	RT versus TMZ alone	584	60	65	3.3 versus 4.7	8.6 versus 9.6

PFS: progression-free survival; OS: overall survival; KPS: Karnofsky Performance Status; RT: radiotherapy; TMZ: temozolomide; NA: not available.