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BioMed Research International
Volume 2014, Article ID 734675, 13 pages
Review Article

Advances in Miniaturized Instruments for Genomics

1Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, Taoyuan 333, Taiwan
2Portable Energy System Group, Green Technology Research Center, College of Engineering, Chang Gung University, Taoyuan 333, Taiwan
3Graduate Institute of Medical Mechatronics, Chang Gung University, Taoyuan 333, Taiwan
4Department of Mechanical Engineering, Chang Gung University, Taoyuan 333, Taiwan

Received 18 December 2013; Revised 21 January 2014; Accepted 30 January 2014; Published 29 May 2014

Academic Editor: Tzu-Chen Yen

Copyright © 2014 Cihun-Siyong Alex Gong and Kin Fong Lei. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In recent years, a lot of demonstrations of the miniaturized instruments were reported for genomic applications. They provided the advantages of miniaturization, automation, sensitivity, and specificity for the development of point-of-care diagnostics. The aim of this paper is to report on recent developments on miniaturized instruments for genomic applications. Based on the mature development of microfabrication, microfluidic systems have been demonstrated for various genomic detections. Since one of the objectives of miniaturized instruments is for the development of point-of-care device, impedimetric detection is found to be a promising technique for this purpose. An in-depth discussion of the impedimetric circuits and systems will be included to provide total consideration of the miniaturized instruments and their potential application towards real-time portable imaging in the “-omics” era. The current excellent demonstrations suggest a solid foundation for the development of practical and widespread point-of-care genomic diagnostic devices.