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BioMed Research International
Volume 2014 (2014), Article ID 734946, 9 pages
Research Article

Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada

1Departamento de Antibióticos, Universidade Federal de Pernambuco, 50670-420 Recife, PE, Brazil
2 Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco, 52171-900 Recife, PE, Brazil
3Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, 50670-420 Recife, PE, Brazil
4Departamento de Microbiologia, Centro de Pesquisa Aggeu Magalh, FIOCRUZ, 50670-420 Recife, PE, Brazil

Received 27 February 2014; Revised 17 June 2014; Accepted 18 June 2014; Published 20 July 2014

Academic Editor: Silvia R. B. Uliana

Copyright © 2014 Eduardo H. S. Ramos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The essential oils from Mangifera indica var. Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS. Twenty-seven components were identified. The main compound in the essential oil from M. indica var. Espada (EOMiE) was terpinolene (73.6%). The essential oil of M. indica var. Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%). In the test for leishmanicidal activity against promastigotes forms of L. amazonensis, EOMiR and EOMiE showed IC50 (72 h) of 39.1 and 23.0 μg/mL, respectively. In macrophages, EOMiR and EOMiE showed CC50 of 142.84 and 158.65 μg/mL, respectively. However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR. The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60. The EOMiR and EOMiE were most effective against the HL-60, with IC50 values of 12.3 and 3.6 μg/mL, respectively. The results demonstrated that the essential oils of M. indica can destroy L. amazonensis and inhibit tumor cell growth. These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.