Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada
Table 3
Cytotoxic activity against human tumor cells of the essential oils from the M. indica var. Rosa and M. indica var. Espada.
Essential oil
aIC50 (g/mL)
HT-29
HEp-2
NCI-292
HL-60
EOMiR
28.7
25.6
38.9
12.3
20.3–30.5
20.5–31.9
31.3–48.4
9.5–15.9
EOMiE
9.2
6.2
14.5
3.6
6.0–14.0
4.4–8.6
11.4–18.4
2.8–4.8
Terpinolene
16.7
13.7
17.4
28.8
13.0–21.6
11.5–16.3
14.8–19.6
25.6–32.3
-Pinene
10.3
11.0
11.8
11.8
8.7–12.2
7.7–15.6
9.1–13.5
10.0–14.0
-Pinene
6.6
6.3
7.5
10.5
5.8–7.5
5.0–8.0
5.1–11.0
9.1–12.0
-3-Carene
45.5
35.0
42.6
63.1
37.6–55.0
29.6–41.2
35.1–51.9
47.4–84.0
Terpinolene (74%) + -3-carene (6%)
22.8
26.5
29.3
27.0
16.4–31.6
22.8–30.8
25.8–33.2
23.03–31.8
-Pinene (41%) + terpinolene (28%) + -pinene (11%)
22.3
30.5
40.1
7.8
16.1–31.1
25.6–36.4
20.6–47.9
5.6–10.7
Terpinolene (74%) + -pinene (2%)
39.4
35.0
30.4
36.0–43.1
27.7–44.38
21.8–42.2
Doxorubicin
0.4
0.7
0.01
0.2
0.3–0.5
0.2–1.4
0.004–0.3
0.01–0.2
Data are presented as IC50 values and 95% confidence intervals obtained by nonlinear regression for all cell lines from two independent experiments. Exposure time: 72 h. HEp-2: larynx carcinoma; NCI-H292: lung mucoepidermoid carcinoma; HT-29: colon adenocarcinoma; and HL-60: promyelocytic leukemia cells. Doxorubicin was used as a positive control. EOMiR: essential oil of M. indica var. Rosa; EOMiE: essential oil of M. indica var. Espada.
