mTOR in Viral Hepatitis and Hepatocellular Carcinoma: Function and Treatment

Figure 3

Regulation and function of mTOR in viral hepatitis and HCC development. In HCV infection, NS5A can activate mTOR through PI3K/Akt pathway or impair the combination between mTOR and FKBP38. The complex formed by mTOR and NF-κB can downregulate the expression of PTEN. In HBV infection, pre-S1 can activate Akt/mTOR pathway through upregulation of VEGFR-2. YY1-HDAC1 complex can inhibit the transcription from the pre-S1 promoter as a negative feedback. HBx can increase the expression of mTOR and PI3K/Akt. S6K can activate PAK1 to regulate actin cytoskeleton and cell motility.