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BioMed Research International
Volume 2014, Article ID 736298, 10 pages
http://dx.doi.org/10.1155/2014/736298
Review Article

The Evolution of Cardiovascular Surgery in Elderly Patient: A Review of Current Options and Outcomes

1Unità di Cardiochirurgia, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Parma, Via A. Gramsci 14, 43126 Parma, Italy
2Unità Operativa di Cardiochirurgia, Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero-Universitaria di Parma, Via A. Gramsci 14, 43126 Parma, Italy

Received 11 February 2014; Accepted 25 March 2014; Published 10 April 2014

Academic Editor: Namal Wijesinghe

Copyright © 2014 Francesco Nicolini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. L. Hannan, H. Kilburn Jr., M. Racz, E. Shields, and M. R. Chassin, “Improving the outcomes of coronary artery bypass surgery in New York State,” Journal of the American Medical Association, vol. 271, no. 10, pp. 761–766, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. W. A. Ghali, A. S. Ash, R. E. Hall, and M. A. Moskowitz, “Statewide quality improvement initiatives and mortality after cardiac surgery,” Journal of the American Medical Association, vol. 277, no. 5, pp. 379–382, 1997. View at Google Scholar · View at Scopus
  3. G. Spencer, Projections of the Population of the United States, By Age, Sex and Race: 1988–2080. Current Population Reports, Population Estimates and ProjectionsGovernment Printing Office, Washington, DC, USA, 1989.
  4. National Center for Health Statistics, Vital Statistics of the United States US Government Printing Office, vol. 2, Washington, DC, USA, 1992.
  5. I. Friedrich, A. Simm, J. Kötting, F. Thölen, B. Fischer, and R. E. Silber, “Cardiac surgery in the elderly patient,” Deutsches Ärzteblatt international, vol. 106, no. 25, pp. 416–422, 2009. View at Google Scholar
  6. D. S. Fruitman, C. E. MacDougall, and D. B. Ross, “Cardiac surgery in octogenarians: can elderly patients benefit? Quality of life after cardiac surgery,” Annals of Thoracic Surgery, vol. 68, no. 6, pp. 2129–2135, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. K. P. Alexander, K. J. Anstrom, L. H. Muhlbaier et al., “Outcomes of cardiac surgery in patients age >or=80 years: results from the national cardiovascular network,” Journal of the American College of Cardiology, vol. 35, no. 3, pp. 731–738, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Trummer and F. Beyersdorf, “Heart surgery in the elderly,” Deutsche Medizinische Wochenschrift, vol. 130, no. 12, pp. 731–734, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Shapira, A. Pines, and R. Mohr, “Updated review of the coronary artery bypass grafting option in octogenarians: good tidings,” American Journal of Geriatric Cardiology, vol. 10, no. 4, pp. 199–204, 2001. View at Google Scholar · View at Scopus
  10. A. Hassan, A. Newman, D. T. Ko et al., “Increasing rates of angioplasty versus bypass surgery in Canada, 1994–2005,” American Heart Journal, vol. 160, no. 5, pp. 958–965, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. D. H. Lee, K. J. Buth, B.-J. Martin, A. M. Yip, and G. M. Hirsch, “Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery,” Circulation, vol. 121, no. 8, pp. 973–978, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Sündermann, A. Dademasch, J. Praetorius et al., “Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery,” European Journal of Cardio-thoracic Surgery, vol. 39, no. 1, pp. 33–37, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. D. B. Loran and J. B. Zwischenberger, “Thoracic surgery in the elderly,” Journal of the American College of Surgeons, vol. 199, no. 5, pp. 773–784, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. E. G. Lakatta, “Cardiovascular aging research: the next horizons,” Journal of the American Geriatrics Society, vol. 47, no. 5, pp. 613–625, 1999. View at Google Scholar · View at Scopus
  15. E. Lakatta, “Aging effects on the vasculature in health: risk factors for cardiovascular disease,” American Journal of Geriatric Cardiology, vol. 3, no. 6, pp. 11–50, 1994. View at Google Scholar · View at Scopus
  16. H.-J. Priebe, “The aged cardiovascular risk patient,” British Journal of Anaesthesia, vol. 85, no. 5, pp. 763–778, 2000. View at Google Scholar · View at Scopus
  17. J. Czernin, P. Muller, S. Chan et al., “Influence of age and hemodynamics on myocardial blood flow and flow reserve,” Circulation, vol. 88, no. 1, pp. 62–69, 1993. View at Google Scholar · View at Scopus
  18. B. Folkow and A. Svanborg, “Physiology of cardiovascular aging,” Physiological Reviews, vol. 73, no. 4, pp. 725–764, 1993. View at Google Scholar · View at Scopus
  19. G. Olivetti, M. Melissari, J. M. Capasso, and P. Anversa, “Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy,” Circulation Research, vol. 68, no. 6, pp. 1560–1568, 1991. View at Google Scholar · View at Scopus
  20. K. Egashira, T. Inou, Y. Hirooka et al., “Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans,” Circulation, vol. 88, no. 1, pp. 77–81, 1993. View at Google Scholar · View at Scopus
  21. M. Amrani, A. T. Goodwin, C. C. Gray, and M. H. Yacoub, “Ageing is associated with reduced basal and stimulated release of nitric oxide by the coronary endothelium,” Acta Physiologica Scandinavica, vol. 157, no. 1, pp. 79–84, 1996. View at Google Scholar · View at Scopus
  22. A. T. Goodwin, M. Amrani, A. J. Marchbank, C. C. Gray, J. Jayakumar, and M. H. Yacoub, “Coronary vasoconstriction to endothelin-1 increases with age before and after ischaemia and reperfusion,” Cardiovascular Research, vol. 41, no. 3, pp. 554–562, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Miyauchi, M. Yanagisawa, K. Iida et al., “Age- and sex-related variation of plasma endothelin-1 concentration in normal and hypertensive subjects,” American Heart Journal, vol. 123, no. 4, pp. 1092–1093, 1992. View at Publisher · View at Google Scholar · View at Scopus
  24. L. P. Fried, C. M. Tangen, J. Walston et al., “Frailty in older adults: evidence for a phenotype,” Journals of Gerontology A Biological Sciences and Medical Sciences, vol. 56, no. 3, pp. M146–M156, 2001. View at Google Scholar · View at Scopus
  25. C. M. Boyd, Q.-L. Xue, C. F. Simpson, J. M. Guralnik, and L. P. Fried, “Frailty, hospitalization, and progression of disability in a cohort of disabled older women,” American Journal of Medicine, vol. 118, no. 11, pp. 1225–1231, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Rockwood, K. Stadnyk, C. MacKnight, I. McDowell, R. Hebert, and D. B. Hogan, “A brief clinical instrument to classify frailty in elderly people,” The Lancet, vol. 353, no. 9148, pp. 205–206, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. R. R. Wolfe, “Optimal nutrition, exercise, and hormonal therapy promote muscle anabolism in the elderly,” Journal of the American College of Surgeons, vol. 202, no. 1, pp. 176–180, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Fried and J. Walston, “Frailty and failure to thrive,” in Principles of Geriatric Gerontology, W. R. Hazzard, J. P. Blass, W. H. Ettinger Jr., J. B. Halter, and J. Ous-lander, Eds., pp. 1487–1502, McGraw Hill, New York, NY, USA, 5th edition, 2003. View at Google Scholar
  29. J. Afilalo, S. Mottillo, M. J. Eisenberg et al., “Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity,” Cardiovascular Quality and Outcomes, vol. 5, pp. 222–228, 2012. View at Publisher · View at Google Scholar
  30. A. Mortasawi, S. Gehle, M. Yaghmaie et al., “Early and long-term results of aortic valve replacement in patients aged 80 years and older,” Herz, vol. 26, no. 2, pp. 140–148, 2001. View at Google Scholar · View at Scopus
  31. M. Di Eusanio, D. Fortuna, D. Cristell et al., “Contemporary outcomes of conventional aortic valve replacement in 638 octogenarians: insights from an Italian Regional Cardiac Surgery Registry (RERIC),” European Journal Cardio-Thoracic Surgery, vol. 41, no. 6, pp. 1247–1253, 2012. View at Publisher · View at Google Scholar
  32. L. H. Cohn and N. Narayanasamy, “Aortic valve replacement in elderly patients: what are the limits?” Current Opinion in Cardiology, vol. 22, no. 2, pp. 92–95, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Brown, S. M. O'Brien, C. Wu, J. A. H. Sikora, B. P. Griffith, and J. S. Gammie, “Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database,” Journal of Thoracic and Cardiovascular Surgery, vol. 137, no. 1, pp. 82–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Lee, S. Li, J. S. Rankin et al., “Fifteen-year outcome trends for valve surgery in North America,” Annals of Thoracic Surgery, vol. 91, no. 3, pp. 677–684, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. J. A. Barreto-Filho, Y. Wang, J. A. Dodson et al., “Trends in aortic valve replacement for elderly patients in the United States 1999–2011,” The Journal of the American Medical Association, vol. 310, no. 19, pp. 2078–2085, 2013. View at Publisher · View at Google Scholar
  36. P. Vaishnava, V. Fuster, M. Goldman, and R. O. Bonow, “Surgery for asymptomatic degenerative aortic and mitral valve disease,” Nature Reviews Cardiology, vol. 8, no. 3, pp. 173–177, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. R. O. Bonow, B. A. Carabello, K. Chatterjee et al., “2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Society of Cardiovascular,” Circulation, vol. 118, no. 15, pp. e523–e661, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. E. A. Ashikhmina, H. V. Schaff, J. A. Dearani et al., “Aortic valve replacement in the elderly: determinants of late outcome,” Circulation, vol. 124, no. 9, pp. 1070–1078, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. B. Iung, G. Baron, E. G. Butchart et al., “A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on valvular heart disease,” European Heart Journal, vol. 24, no. 13, pp. 1231–1243, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. C. R. Smith, M. B. Leon, M. J. Mack et al., “Transcatheter versus surgical aortic-valve replacement in high-risk patients,” The New England Journal of Medicine, vol. 364, no. 23, pp. 2187–2198, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Himbert, F. Descoutures, N. Al-Attar et al., “Results of transfemoral or transapical aortic valve implantation following a uniform assessment in high-risk patients with aortic stenosis,” Journal of the American College of Cardiology, vol. 54, no. 4, pp. 303–311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. A. D'Onofrio, M. Fusari, N. Abbiate et al., “Transapical aortic valve implantation in high-risk patients with severe aortic valve stenosis,” Annals of Thoracic Surgery, vol. 92, no. 5, pp. 1671–1677, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Tamburino, D. Capodanno, A. Ramondo et al., “Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis,” Circulation, vol. 123, no. 3, pp. 299–308, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. H. McKellar, M. L. Brown, R. L. Frye, H. V. Schaff, and T. M. Sundt III, “Comparison of coronary revascularization procedures in octogenarians: a systematic review and meta-analysis,” Nature Clinical Practice Cardiovascular Medicine, vol. 5, no. 11, pp. 738–746, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Nissinen, J.-O. Wistbacka, P. Loponen et al., “Coronary artery bypass surgery in octogenarians: long-term outcome can be better than expected,” Annals of Thoracic Surgery, vol. 89, no. 4, pp. 1119–1124, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Filsoufi, P. B. Rahmanian, J. G. Castillo, J. Chikwe, G. Silvay, and D. H. Adams, “Results and predictors of early and late outcomes of coronary artery bypass graft surgery in octogenarians,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 21, no. 6, pp. 784–792, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. R. Baskett, K. Buth, W. Ghali et al., “Outcomes in octogenarians undergoing coronary artery bypass grafting,” Canadian Medical Association Journal, vol. 172, no. 9, pp. 1183–1186, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Nicolini, A. Molardi, D. Verdichizzo et al., “Coronary artery surgery in octogenarians: evolving strategies for the improvement in early and late results,” Heart and Vessels, vol. 27, pp. 559–567, 2012. View at Publisher · View at Google Scholar · View at Scopus
  49. C. J. Mullany, G. E. Darling, J. R. Pluth et al., “Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older,” Circulation, vol. 82, no. 5, pp. IV229–IV236, 1990. View at Google Scholar · View at Scopus
  50. M. Singh, V. Mathew, K. N. Garratt et al., “Effect of age on the outcome of angioplasty for acute myocardial infarction among patients treated at the Mayo Clinic,” American Journal of Medicine, vol. 108, no. 3, pp. 187–192, 2000. View at Publisher · View at Google Scholar · View at Scopus
  51. W. J. Rogers, E. L. Alderman, B. R. Chaitman et al., “Bypass Angioplasty Revascularization Investigation (BARI): baseline clinical and angiographic data,” American Journal of Cardiology, vol. 75, no. 9, pp. 9C–17C, 1995. View at Publisher · View at Google Scholar · View at Scopus
  52. S. N. Hoffman, J. A. TenBrook Jr., M. P. Wolf, S. G. Pauker, D. N. Salem, and J. B. Wong, “A meta-analysis of randomized controlled trials comparing coronary artery bypass graft with percutaneous transluminal coronary angioplasty: one- to eight-year outcomes,” Journal of the American College of Cardiology, vol. 41, no. 8, pp. 1293–1304, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. J. Gunn, K. Kuttila, F. Vasques et al., “Comparison of results of coronary artery bypass grafting versus percutaneous coronary intervention in octogenarians,” American Journal of Cardiology, vol. 110, no. 8, pp. 1125–1129, 2012. View at Publisher · View at Google Scholar
  54. N. Wongcharoenkiat, D. Tresukosol, P. Laksanabunsong, and S. Udompunturak, “A comparison of outcomes between percutaneous coronary intervention versus coronary artery bypass surgery in octogenarian patients,” Journal of the Medical Association of Thailand, vol. 95, supplement 2, pp. S154–S164, 2012. View at Google Scholar
  55. Y. Ben-Gal, A. Finkelstein, S. Banai et al., “Surgical myocardial revascularization versus percutaneous coronary intervention with drug-eluting stents in octogenarian patients,” The Heart Surgery Forum, vol. 15, no. 4, pp. E204–E209, 2012. View at Publisher · View at Google Scholar
  56. M. Pfisterer, “Trial of invasive versus medical therapy in elderly patients with chronic symptomatic coronary-artery disease (TIME): a randomised trial,” The Lancet, vol. 358, no. 9286, pp. 951–957, 2001. View at Publisher · View at Google Scholar · View at Scopus
  57. M. M. Graham, W. A. Ghali, P. D. Faris, P. D. Galbraith, C. M. Norris, and M. L. Knudtson, “Survival after coronary revascularization in the elderly,” Circulation, vol. 105, no. 20, pp. 2378–2384, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. W. B. Batchelor, K. J. Anstrom, L. H. Muhlbaier et al., “Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: results in 7,472 octogenarians,” Journal of the American College of Cardiology, vol. 36, no. 3, pp. 723–730, 2000. View at Publisher · View at Google Scholar · View at Scopus
  59. J. De Gregorio, Y. Kobayashi, R. Albiero et al., “Coronary artery stenting in the elderly: short-term outcome and long- term angiographic and clinical follow-up,” Journal of the American College of Cardiology, vol. 32, no. 3, pp. 577–583, 1998. View at Publisher · View at Google Scholar · View at Scopus
  60. G. J. Kowalchuk, S. C. Siu, and S. M. Lewis, “Coronary artery disease in the octogenarian: angiographic spectrum and suitability for revascularization,” American Journal of Cardiology, vol. 66, no. 19, pp. 1319–1323, 1990. View at Publisher · View at Google Scholar · View at Scopus
  61. L. W. Klein, P. Block, R. G. Brindis et al., “Percutaneous coronary interventions in octogenarians in the American College of Cardiology-National Cardiovascular Data Registry: development of a nomogram predictive of in-hospital mortality,” Journal of the American College of Cardiology, vol. 40, no. 3, pp. 394–402, 2002. View at Publisher · View at Google Scholar · View at Scopus
  62. J. B. Hermiller, E. Nikolsky, A. J. Lansky et al., “Clinical and angiographic outcomes of elderly patients treated with everolimus-eluting versus paclitaxel-eluting stents: three-year results from the SPIRIT III randomised trial,” EuroIntervention, vol. 7, no. 3, pp. 307–313, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. M. H. Hedeshian, N. Namour, E. Dziadik, R. D. Stewart, and C. T. Campos, “Does increasing age have a negative impact on six-month functional outcome after coronary artery bypass?” Surgery, vol. 132, no. 2, pp. 239–244, 2002. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Natarajan, S. Samadian, and S. Clark, “Coronary artery bypass surgery in elderly people,” Postgraduate Medical Journal, vol. 83, no. 977, pp. 154–158, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. B. Zingone, G. Gatti, E. Rauber et al., “Early and late outcomes of cardiac surgery in octogenerians,” Annals of Thoracic Surgery, vol. 87, no. 1, pp. 71–78, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. M. Maganti, V. Rao, S. Brister, and J. Ivanov, “Decreasing mortality for coronary artery bypass surgery in octogenarians,” Canadian Journal of Cardiology, vol. 25, no. 2, pp. e32–e35, 2009. View at Google Scholar · View at Scopus
  67. M. A. Hlatky, D. B. Boothroyd, D. M. Bravata et al., “Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials,” The Lancet, vol. 373, no. 9670, pp. 1190–1197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. M. F. Wilson, M. K. Baig, and H. Ashraf, “Quality of life in octagenarians after coronary artery bypass grafting,” American Journal of Cardiology, vol. 95, no. 6, pp. 761–764, 2005. View at Publisher · View at Google Scholar · View at Scopus
  69. L. J. Dacey, D. S. Likosky, T. J. Ryan Jr. et al., “Long-term survival after surgery versus percutaneous intervention in octogenarians with multivessel coronary disease,” Annals of Thoracic Surgery, vol. 84, no. 6, pp. 1904–1911, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. G. A. Contini, F. Nicolini, D. Fortuna et al., “Five-year outcomes of surgical or percutaneous myocardial revascularization in diabetic patients,” International Journal of Cardiology, vol. 168, no. 2, pp. 1028–1033, 2013. View at Publisher · View at Google Scholar
  71. N. T. Artinian, C. Duggan, and P. Miller, “Age differences in patient recovery patterns following coronary artery bypass surgery,” American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses, vol. 2, no. 6, pp. 453–461, 1993. View at Google Scholar · View at Scopus
  72. J. S. Rumsfeld, D. J. Magid, M. O'Brien et al., “Changes in health-related quality of life following coronary artery bypass graft surgery,” Annals of Thoracic Surgery, vol. 72, no. 6, pp. 2026–2032, 2001. View at Publisher · View at Google Scholar · View at Scopus
  73. L. Shan, A. Saxena, R. McMahon, and A. Newcomb, “Coronary artery bypass graft surgery in the elderly. A review of postoperative quality of life,” Circulation, vol. 128, pp. 2333–2343, 2013. View at Publisher · View at Google Scholar
  74. S. G. Raja and G. D. Dreyfus, “Impact of off-pump coronary artery bypass surgery on postoperative renal dysfunction: current best available evidence,” Nephrology, vol. 11, no. 4, pp. 269–273, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. S. G. Raja and G. A. Berg, “Impact of off-pump coronary artery bypass surgery on systemic inflammation: current best available evidence,” Journal of Cardiac Surgery, vol. 22, no. 5, pp. 445–455, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. L. Marti, C. Cervera, X. Filella, J. L. Marin, M. Almela, and A. Moreno, “Cytokine-release patterns in elderly patients with systemic inflammatory response syndrome,” Gerontology, vol. 53, no. 5, pp. 239–244, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. A. Parolari, F. Alamanni, A. Cannata et al., “Off-pump versus on-pump coronary artery bypass: meta-analysis of currently available randomized trials,” Annals of Thoracic Surgery, vol. 76, no. 1, pp. 37–40, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. J. T. Reston, S. J. Tregear, and C. M. Turkelson, “Meta-analysis of short-term and mid-term outcomes following off-pump coronary artery bypass grafting,” Annals of Thoracic Surgery, vol. 76, no. 5, pp. 1510–1515, 2003. View at Publisher · View at Google Scholar · View at Scopus
  79. S. G. Raja and G. D. Dreyfus, “Impact of off-pump coronary artery bypass surgery on postoperative renal dysfunction: current best available evidence,” Nephrology, vol. 11, no. 4, pp. 269–273, 2006. View at Publisher · View at Google Scholar · View at Scopus
  80. H. Z. Saleh, M. Shaw, B. M. Fabri, and J. A. C. Chalmers, “Does avoidance of cardiopulmonary bypass confer any benefits in octogenarians undergoing coronary surgery?” Interactive Cardiovascular and Thoracic Surgery, vol. 12, no. 3, pp. 435–439, 2011. View at Publisher · View at Google Scholar · View at Scopus
  81. D. J. LaPar, C. M. Bhamidipati, T. B. Reece, J. C. Cleveland, I. L. Kron, and G. Ailawadi, “Is off-pump coronary artery bypass grafting superior to conventional bypass in octogenarians?” Journal of Thoracic and Cardiovascular Surgery, vol. 141, no. 1, pp. 81–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  82. B. Ø. Jensen, L. S. Rasmussen, and D. A. Steinbrüchel, “Cognitive outcomes in elderly high-risk patients 1 year after off-pump versus on-pump coronary artery bypass grafting. A randomized trial,” European Journal of Cardio-thoracic Surgery, vol. 34, no. 5, pp. 1016–1021, 2008. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Tugtekin, U. Kappert, K. Alexiou, M. Wilbring, A. D. Nagpal, and K. Matschke, “Coronary artery bypass grafting in octogenarians—outcome with and without extracorporeal circulation,” Thoracic and Cardiovascular Surgeon, vol. 55, no. 7, pp. 407–411, 2007. View at Publisher · View at Google Scholar · View at Scopus
  84. M. Meco, T. Biraghi, P. Panisi, F. Casselman, D. Cosseta, and S. Cirri, “Aortocoronary bypass grafting in high-risk patients over 75 years. Propensity score analysis of on versus off-pump early and midterm results,” Journal of Cardiovascular Surgery, vol. 48, no. 3, pp. 339–347, 2007. View at Google Scholar · View at Scopus
  85. S. C. Stamou, G. Dangas, M. K. C. Dullum et al., “Beating heart surgery in octogenarians: perioperative outcome and comparison with younger age groups,” Annals of Thoracic Surgery, vol. 69, no. 4, pp. 1140–1145, 2000. View at Publisher · View at Google Scholar · View at Scopus
  86. J. D. Puskas, A. D. Winston, C. E. Wright et al., “Stroke after coronary artery operation: incidence, correlates, outcome, and cost,” Annals of Thoracic Surgery, vol. 69, no. 4, pp. 1053–1056, 2000. View at Publisher · View at Google Scholar · View at Scopus
  87. T. Athanasiou, S. Al-Ruzzeh, P. Kumar et al., “Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patients,” Annals of Thoracic Surgery, vol. 77, no. 2, pp. 745–753, 2004. View at Publisher · View at Google Scholar · View at Scopus
  88. S. S. Panesar, T. Athanasiou, S. Nair et al., “Early outcomes in the elderly: a meta-analysis of 4921 patients undergoing coronary artery bypass grafting—Comparison between off-pump and on-pump techniques,” Heart, vol. 92, no. 12, pp. 1808–1816, 2006. View at Publisher · View at Google Scholar · View at Scopus
  89. V. Zamvar, D. Williams, J. Hall et al., “Assessment of neurocognitive impairment after off-pump and on-pump techniques for coronary artery bypass graft surgery: prospective randomised controlled trial,” British Medical Journal, vol. 325, no. 7375, pp. 1268–1271, 2002. View at Google Scholar · View at Scopus
  90. J. D. Lee, S. J. Lee, W. T. Tsushima et al., “Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trial,” Annals of Thoracic Surgery, vol. 76, no. 1, pp. 18–26, 2003. View at Publisher · View at Google Scholar · View at Scopus
  91. T. Athanasiou, O. Aziz, O. Mangoush et al., “Do off-pump techniques reduce the incidence of postoperative atrial fibrillation in elderly patients undergoing coronary artery bypass grafting?” Annals of Thoracic Surgery, vol. 77, no. 5, pp. 1567–1574, 2004. View at Publisher · View at Google Scholar · View at Scopus
  92. T. Athanasiou, O. Aziz, O. Mangoush et al., “Does off-pump coronary artery bypass reduce the incidence of post-operative atrial fibrillation? A question revisited,” European Journal of Cardio-thoracic Surgery, vol. 26, no. 4, pp. 701–710, 2004. View at Publisher · View at Google Scholar · View at Scopus
  93. G. Maitra, A. Ahmed, A. Rudra et al., “Renal dysfunction after off-pump coronary artery bypass surgery- risk factors and preventive strategies,” Indian Journal of Anaesthesia, vol. 53, no. 4, pp. 401–407, 2009. View at Google Scholar
  94. A. Weerasinghe, T. Athanasiou, S. Al-Ruzzeh et al., “Functional renal outcome in on-pump and off-pump coronary revascularization: a propensity-based analysis,” Annals of Thoracic Surgery, vol. 79, no. 5, pp. 1577–1583, 2005. View at Publisher · View at Google Scholar · View at Scopus
  95. S. U. Nigwekar, P. Kandula, J. K. Hix, and C. V. Thakar, “Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies,” American Journal of Kidney Diseases, vol. 54, no. 3, pp. 413–423, 2009. View at Publisher · View at Google Scholar · View at Scopus
  96. T. Kleisli, W. Cheng, M. J. Jacobs et al., “In the current era, complete revascularization improves survival after coronary artery bypass surgery,” Journal of Thoracic and Cardiovascular Surgery, vol. 129, no. 6, pp. 1283–1291, 2005. View at Publisher · View at Google Scholar · View at Scopus
  97. R. O. Bonow, B. A. Carabello, K. Chatterjee et al., “2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease),” Circulation, vol. 118, no. 15, pp. e523–e661, 2008. View at Publisher · View at Google Scholar · View at Scopus
  98. J. S. Gammie, S. Sheng, B. P. Griffith et al., “Trends in mitral valve surgery in the United States: results from The Society of Thoracic Surgeons Adult Cardiac Database,” Annals of Thoracic Surgery, vol. 87, no. 5, pp. 1431–1439, 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. O. Alfieri and F. Maisano, “Mitral valve surgery in the elderly: new insights and unanswered questions,” European Heart Journal, vol. 32, no. 5, pp. 535–536, 2011. View at Publisher · View at Google Scholar · View at Scopus
  100. M. G. Sutton and R. C. Gorman, “Surgery for asymptomatic severe mitral regurgitation in the elderly: Early surgery or wait and watch?” Circulation, vol. 114, no. 4, pp. 258–260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  101. R. Rosenhek, F. Rader, U. Klaar et al., “Outcome of watchful waiting in asymptomatic severe mitral regurgitation,” Circulation, vol. 113, no. 18, pp. 2238–2244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  102. J. Chikwe, A. B. Goldstone, J. Passage et al., “A propensity score-adjusted retrospective comparison of early and mid-term results of mitral valve repair versus replacement in octogenarians,” European Heart Journal, vol. 32, no. 5, pp. 618–626, 2011. View at Publisher · View at Google Scholar · View at Scopus
  103. G. Ailawadi, B. R. Swenson, M. E. Girotti et al., “Is mitral valve repair superior to replacement in elderly patients?” Annals of Thoracic Surgery, vol. 86, no. 1, pp. 77–86, 2008. View at Publisher · View at Google Scholar · View at Scopus
  104. M. A. Daneshmand, C. A. Milano, J. S. Rankin et al., “Influence of patient age on procedural selection in mitral valve surgery,” Annals of Thoracic Surgery, vol. 90, no. 5, pp. 1479–1485, 2010. View at Publisher · View at Google Scholar · View at Scopus
  105. V. H. Thourani, W. S. Weintraub, R. A. Guyton et al., “Outcomes and long-term survival for patients undergoing mitral valve repair versus replacement: effect of age and concomitant coronary artery bypass grafting,” Circulation, vol. 108, no. 3, pp. 298–304, 2003. View at Publisher · View at Google Scholar · View at Scopus
  106. R. Lorusso, S. Gelsomino, E. Vizzardi et al., “Mitral valve repair or replacement for ischemic mitral regurgitation? The Italian Study on the Treatment of Ischemic Mitral Regurgitation (ISTIMIR),” The Journal of Thoracic and Cardiovascular Surgery, vol. 145, no. 1, pp. 128–139, 2013. View at Publisher · View at Google Scholar
  107. A. M. Gillinov, E. H. Blackstone, E. R. Nowicki et al., “Valve repair versus valve replacement for degenerative mitral valve disease,” Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 4, pp. 885–893, 2008. View at Publisher · View at Google Scholar · View at Scopus
  108. J. Chikwe and F. Filsoufi, “Durability of tissue valves,” Seminars in Thoracic and Cardiovascular Surgery, vol. 23, no. 1, pp. 18–23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  109. V. Badhawar, E. D. Peterson, J. P. Jacob et al., “Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007,” The Annals of Thoracic Surgery, vol. 94, no. 6, pp. 1870–1879, 2012. View at Publisher · View at Google Scholar
  110. T. Feldman, “Proceedings of TCT: current status of catheter-based mitral valve repair therapies,” Journal of Interventional Cardiology, vol. 19, no. 5, pp. 396–400, 2006. View at Publisher · View at Google Scholar · View at Scopus
  111. F. Maisano, N. Buzzatti, M. Taramasso, and O. Alfieri, “Mitral transcatheter technologies,” Rambam Maimonides Medical Journal, vol. 4, no. 3, p. e0015, 2013. View at Publisher · View at Google Scholar
  112. T. T. Tsai, S. Trimarchi, and C. A. Nienaber, “Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD),” European Journal of Vascular and Endovascular Surgery, vol. 37, no. 2, pp. 149–159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  113. Y.-C. Chen and R.-B. Hsu, “Aortic surgery requiring hypothermic circulatory arrest in octogenarians,” Journal of the Formosan Medical Association, vol. 107, no. 5, pp. 412–418, 2008. View at Publisher · View at Google Scholar · View at Scopus
  114. E. Apostolakis, E. N. Koletsis, P. Dedeilias et al., “Antegrade versus retrograde cerebral perfusion in relation to postoperative complications following aortic arch surgery for acute aortic dissection type A,” Journal of Cardiac Surgery, vol. 23, no. 5, pp. 480–487, 2008. View at Publisher · View at Google Scholar · View at Scopus
  115. E. Neri, T. Toscano, M. Massetti et al., “Operation for acute type A aortic dissection in octogenarians: is it justified?” Journal of Thoracic and Cardiovascular Surgery, vol. 121, no. 2, pp. 259–267, 2001. View at Publisher · View at Google Scholar · View at Scopus
  116. M. Hata, A. Sezai, T. Niino et al., “Should emergency surgical intervention be performed for an octogenarian with type A acute aortic dissection?” Journal of Thoracic and Cardiovascular Surgery, vol. 135, no. 5, pp. 1042–1046, 2008. View at Publisher · View at Google Scholar · View at Scopus
  117. A. Piccardo, T. Regesta, K. Zannis et al., “Outcomes after surgical treatment for type A acute aortic dissection in octogenarians: a multicenter study,” Annals of Thoracic Surgery, vol. 88, no. 2, pp. 491–497, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. F. Biancari, F. Vasques, V. Benenati, and T. Juvonen, “Contemporary results after surgical repair of type A aortic dissection in patients aged 80 years and older: a systematic review and meta-analysis,” European Journal of Cardio-thoracic Surgery, vol. 40, no. 5, pp. 1058–1063, 2011. View at Publisher · View at Google Scholar · View at Scopus