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BioMed Research International
Volume 2014, Article ID 736786, 6 pages
http://dx.doi.org/10.1155/2014/736786
Research Article

Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis: A Cross-Sectional Study in a Mexican Population

1Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Benemérita Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
2Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Benemérita Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
3Servivio de Radiología e Imagen, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Benemérita Universidad de Guadalajara, Hospital No. 278, 44280 Guadalajara, JAL, Mexico
4Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Benemérita Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico
5Departamento de Medicina Interna-Reumatología, Hospital General Regional No. 110, Instituto Mexicano del Seguro Social, ICircunvalación Oblatos No. 2212, Colonia Oblatos, 44700 Guadalajara, JAL, Mexico
6Unidad Médica de Alta Especialidad, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Belisario Domínguez No. 1000, Independencia Oriente, 44340 Guadalajara, JAL, Mexico
7Servicio de Reumatología, Hospital Civil “Dr. Juan I. Menchaca”, Benemérita Universidad de Guadalajara, Salvador de Quevedo No. 750, 44100 Guadalajara, JAL, Mexico

Received 20 March 2014; Revised 13 May 2014; Accepted 13 May 2014; Published 9 June 2014

Academic Editor: Miguel A. González-Gay

Copyright © 2014 Eduardo Gómez-Bañuelos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis. There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA. The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and carotid intima-media thickness (cIMT) in patients with RA. Methods. We included 67 patients with RA from the Rheumatology Department of Hospital Civil “Dr. Juan I. Menchaca,” Guadalajara, Jalisco, Mexico. We evaluated the cIMT, considering subclinical atherosclerosis when >0.6 mm. Since our main objective was to associate the membrane expression of CD36 with subclinical atherosclerosis, other molecules related with cardiovascular risk such as ox-LDL, IL-6, and TNF were tested. Results. We found low CD36 membrane expression in PBMC from RA patients with subclinical atherosclerosis (). CD36 mean fluorescence intensity had negative correlations with cIMT (r = −0.578, ), ox-LDL (r = −0.427, P = 0.05), TNF (r = −0.729, ), and IL-6 (r = −0.822, ). Conclusion. RA patients with subclinical atherosclerosis showed low membrane expression of CD36 in PBMC and increased serum proinflammatory cytokines. Further studies are needed to clarify the regulation of CD36 in RA.