Review Article

Role of G Protein-Coupled Receptors in Control of Dendritic Cell Migration

Table 1

Chemokine receptors and chemokines involved in migration of mouse DCs subsets.

ReceptorLigandsCellular distributionRole in migrationReference

CCR1 MIP-1 /CCL9 Immature DCsRecruitment of CD11b+ DCs to the dome regions of Peyer’s patch [22]
Recruitment of DC precursors into airway epithelium during bacterial inflammation and steady-state[23]

CCR2 CCL2/MCP-1 Immature DCsRecruitment of DCs in the lung during allergic inflammation, and supposed to be critical in inducing T(H)2 responses[24, 25]
Recruitment of CD11cdim/intermediate DCs in the lung during mycobacterium tuberculosis infection and cDCs during Cryptococcus neoformans infection, may be important in inducing T(H)1 responses[26, 27]
Mature DCsActivated LC migrate from skin to draining LNs and regulate infection-induced relocalization of CD11c+ DC in spleen[28]

CCR5MIP-1 /CCL3
MIP-1 /CCL4
Rantes/CCL5
Immature DCs
mature DCs
Recruitment of pDC to inflamed peripheral lymph nodes[29]

CCR6CCL20/MIP-3 Immature myeloid DC, subsets of pDCsRecruitment of myeloid CD11c+ CD11b+ dendritic cells to the dome regions of Peyer's patches [30, 31]
Recruitment of myeloid DCs to the inflamed epithelial tissues such as skin[32]
mediate pDC recruitment to inflamed epithelia[33]

CCR7 CCL19/MIP-3
CCL21/SLC
Mature DCsessential for directing the antigen-loaded mature cDCs to the T cell-rich areas of the draining lymph node during inflammatory and steady-state conditions[34]
Migration of pDCs to LNs via HEV under both steady-state and inflammatory conditions[35]
Migration of pDC to the splenic white pulp under steady-state conditions[36]

CCR9CCL25Myeloid and pDCControls the migration of pDC to the small intestine under both steady-state and inflammatory conditions[37]

CCR10CCL27
CCL28
Subset of tonsil pDCs,
IL-3-cultured blood pDCs
Mediate pDC homing into inflamed epithelia[33]

CXCR3CXCL9
CXCL10/IP-10
CXCL11
pDC precursors
pDC
CD11c+ myeloid DCs
monocyte-derived iDC
Migration of pDC to inflamed LNs via HEV[38]
migration and clustering of splenic plasmacytoid DCs in the spleen marginal zone 
  
[39]

CXCR4CXCL12/SDF-1 Immature DCs
mature DCs
pDC
Migration of skin dendritic cells to LNs[40]
Migration of pDC to the splenic white pulp under steady-state conditions[36]

CXCR5CXCL13/BLC/BCA-1Activated skin DCActivated dermal DC migrate to draining LNs[41]