Proinflammatory Cytokines Correlate with Depression and Anxiety in Colorectal Cancer Patients

Table 3

Correlation between serum levels of cytokines and HADS score.

	IL-1	IL-6	IL-8	IL-10	IL-12	TNF-α	TGF-β
Control group
Anxiety (HADS)	0.19	0.12	0.18	−0.14	0.11	0.15	−0.11
Depression (HADS)	0.12	0.13	0.12	−0.17	0.17	0.08	−0.12
D and A (total HADS)	0.12	0.14	0.22	−0.16	0.14	0.09	−0.12
CRC patients
Anxiety (HADS)	0.48***	0.49***	0.62***	−0.36**	−0.14	0.29*	−0.19
Depression (HADS)	0.49**	0.36**	0.44**	−0.25*	−0.02	0.28*	−0.15
D and A (total HADS)	0.59***	0.49***	0.65***	−0.21*	−0.05	0.35**	−0.11

HADS: Hospital Anxiety and Depression Scale.
D and A: depression and anxiety combined (total HADS).
Values represent the coefficient of determination () for simple linear regression.
Correlation is significant at * < 0.05, ** < 0.001, and *** < 0.0001.