Tumor Necrosis Factor-Alpha −308 G>A Polymorphism, Adherence to Mediterranean Diet, and Risk of Overweight/Obesity in Young Women

Table 5

TNFA  −308 G>A polymorphism and saturated fatty acids intake interactions on overweight/obesity risk^a,b.

Fatty acids	A^c; OR (95% CI)	B^d; OR (95% CI)	A+B^e; OR (95% CI)	Synergy index
Palmitic acid	0.94 (0.50–1.76)	0.26 (0.13–0.53)	1.34 (0.49–3.71)	—
Saturated fatty acids	1.11 (0.59–2.10)	0.29 (0.15–0.59)	0.90 (0.33–2.43)	—

aOR adjusted for age, adherence to MD, and education.
^bReference category: individuals carrying the homozygous wild-type genotype GG, who had not been exposed to environmental factor.
^cA: risk of developing overweight/obesity in carriers of TNFA  −308 A allele (individuals carrying the homozygous mutated genotype or the heterozygous genotype AA or AG, who had not been exposed to environmental factor-FAs intakes below the 75th percentile of the saturated FAs intakes distribution).
^dB: risk of developing overweight/obesity in women exposed to environmental factor only (individuals carrying the homozygous wild-type genotype GG, who had been exposed to environmental factor-FAs intakes above the 75th percentile of the saturated FAs intakes distribution).
^eA+B: risk of developing overweight/obesity in women exposed to both A and B (individuals carrying the homozygous mutated genotype or the heterozygous genotype AA or AG, who had been exposed to environmental factor-FAs intakes above the 75th percentile of the saturated FAs intakes distribution).