TY - JOUR
A2 - Kneser, Ulrich
AU - Zhang, Weijie
AU - Lian, Qin
AU - Li, Dichen
AU - Wang, Kunzheng
AU - Hao, Dingjun
AU - Bian, Weiguo
AU - He, Jiankang
AU - Jin, Zhongmin
PY - 2014
DA - 2014/08/07
TI - Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea
SP - 746138
VL - 2014
AB - Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ. However, the exact change of subchondral bone during osteochondral repair is still poorly understood. In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model. Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation. Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks. The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually. Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage. Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects. Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.
SN - 2314-6133
UR - https://doi.org/10.1155/2014/746138
DO - 10.1155/2014/746138
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -