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BioMed Research International
Volume 2014 (2014), Article ID 747584, 8 pages
http://dx.doi.org/10.1155/2014/747584
Review Article

The Role of the Extracellular Matrix Components in Cutaneous Wound Healing

1Department of Community Pharmacy, Medical University of Silesia, ul. Kasztanowa 3, 41-200 Sosnowiec, Poland
2Department of Clinical Chemistry and Laboratory Diagnostics, Medical University of Silesia, ul. Jednosci 8, 41-200 Sosnowiec, Poland

Received 11 December 2013; Revised 13 February 2014; Accepted 17 February 2014; Published 17 March 2014

Academic Editor: Tomasz Urbanek

Copyright © 2014 Pawel Olczyk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Watson”, “Soft tissue repair and healing review,” Tissue Repair, 2012, http://www.electrotherapy.org .
  2. H. Sinno and S. Prakash, “Complements and the wound healing cascade: an updated review,” Plastic Surgery International, vol. 2013, Article ID 146764, 7 pages, 2013. View at Publisher · View at Google Scholar
  3. S. Guo and L. A. DiPietro, “Critical review in oral biology & medicine: factors affecting wound healing,” Journal of Dental Research, vol. 89, no. 3, pp. 219–229, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. S. Midwood, L. V. Williams, and J. E. Schwarzbauer, “Tissue repair and the dynamics of the extracellular matrix,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 6, pp. 1031–1037, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Raghow, “The role of extracellular matrix in postinflammatory wound healing and fibrosis,” The FASEB Journal, vol. 8, no. 11, pp. 823–831, 1994. View at Google Scholar · View at Scopus
  6. M. C. Robson, “Cytokine manipulation of the wound,” Clinics in Plastic Surgery, vol. 30, no. 1, pp. 57–65, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. B. M. Dulmovits and I. M. Herman, “Microvascular remodeling and wound healing: a role for pericytes,” International Journal of Biochemistry & Cell Biology, vol. 44, pp. 1800–1812, 2012. View at Google Scholar
  8. G. Broughton II, J. E. Janis, and C. E. Attinger, “The basic science of wound healing,” Plastic and Reconstructive Surgery, vol. 117, supplement 7, pp. 12S–34S, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Fuchs and J. A. Nowak, “Building epithelial tissues from skin stem cells,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 73, pp. 333–350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. V. W. Wong, B. Levi, J. Rajadas, M. T. Longaker, and G. C. Gurtner, “Stem cell niches for skin regeneration,” International Journal of Biomaterials, vol. 2012, Article ID 926059, 8 pages, 2012. View at Publisher · View at Google Scholar
  11. J. Muto, N. N. Naidu, K. Yamasaki, N. Pineau, L. Breton, and R. L. Gallo, “Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration,” PLoS ONE, vol. 6, no. 10, Article ID e25480, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. G. S. Schultz and A. Wysocki, “Interactions between extracellular matrix and growth factors in wound healing,” Wound Repair and Regeneration, vol. 17, no. 2, pp. 153–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. G. S. Schultz, J. M. Davidson, R. S. Kirsner, P. Bornstein, and I. M. Herman, “Dynamic reciprocity in the wound microenvironment,” Wound Repair and Regeneration, vol. 19, no. 2, pp. 134–148, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. J. P. Hodde and C. E. Johnson, “Extracellular matrix as a strategy for treating chronic wounds,” American Journal of Clinical Dermatology, vol. 8, no. 2, pp. 61–66, 2007. View at Google Scholar · View at Scopus
  15. R. F. Diegelmann and M. C. Evans, “Wound healing: an overview of acute, fibrotic and delayed healing,” Frontiers in Bioscience, vol. 9, pp. 283–289, 2004. View at Google Scholar · View at Scopus
  16. P. Bainbridge, “Wound healing and the role of fibroblasts,” Journal of Wound Care, vol. 22, no. 8, pp. 407–412, 2013. View at Google Scholar
  17. M. S. Ågren and M. Werthén, “The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds,” International Journal of Lower Extremity Wounds, vol. 6, no. 2, pp. 82–97, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. K. T. Tran, L. Griffith, and A. Wells, “Extracellular matrix signaling through growth factor receptors during wound healing,” Wound Repair and Regeneration, vol. 12, no. 3, pp. 262–268, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. K. F. Cutting, “Wound healing through synergy of hyaluronan and an iodine complex,” Journal of Wound Care, vol. 20, no. 9, pp. 424–430, 2011. View at Google Scholar · View at Scopus
  20. J. S. Frenkel, “The role of hyaluronan in wound healing,” International Wound Journal, 2012. View at Publisher · View at Google Scholar
  21. R. Raman, V. Sasisekharan, and R. Sasisekharan, “Structural Insights into biological roles of protein-glycosaminoglycan interactions,” Chemistry and Biology, vol. 12, no. 3, pp. 267–277, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Broughton II, J. E. Janis, and C. E. Attinger, “Wound healing: an overview,” Plastic and Reconstructive Surgery, vol. 117, no. 7, supplement, pp. 1e-S–32e-S, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Takehara, “Growth regulation of skin fibroblasts,” Journal of Dermatological Science, vol. 24, no. 1, pp. S70–S77, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Barrientos, O. Stojadinovic, M. S. Golinko, H. Brem, and M. Tomic-Canic, “Growth factors and cytokines in wound healing,” Wound Repair and Regeneration, vol. 16, no. 5, pp. 585–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Matsukura, Y. Yokoyama, K. Tanaka, T. Ozaki, and H. Mizunuma, “Changes of proteoglycan expression and glycosaminoglycan constituents in the intervillous space of the pregnancy-induced hypertension placenta,” The Hirosaki Medical Journal, vol. 59, no. 2–4, pp. 128–135, 2008. View at Google Scholar · View at Scopus
  26. J. A. Deakin, B. S. Blaum, J. T. Gallagher, D. Uhrín, and M. Lyo, “The binding properties of minimal oligosaccharides reveal a common heparan sulfate/dermatan sulfate-binding site in hepatocyte growth factor/scatter factor that can accommodate a wide variety of sulfation patterns,” The Journal of Biological Chemistry, vol. 284, no. 10, pp. 6311–6321, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. D. G. Seidler, J. Peter-Katalinić, and A. D. Zamfir, “Galactosaminoglycan function and oligosaccharide structure determination,” The Scientific World Journal, vol. 7, pp. 233–241, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Olczyk, K. Komosinska-Vassev, K. Winsz-Szczotka, J. Stojko, K. Klimek, and E. Kozma, “Propolis induces chondroitin/dermatan sulphate and hyaluronic acid accumulation in the skin of burned wound,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 290675, 8 pages, 2013. View at Publisher · View at Google Scholar
  29. A. Im and Y. S. Kim, “Role of glycosaminoglycans in wound healing,” Archives of Pharmaceutical Sciences and Research, vol. 1, no. 2, pp. 106–114, 2009. View at Google Scholar
  30. Y. Wegrowski, A.-L. Milard, G. Kotlarz, E. Toulmonde, F.-X. Maquart, and J. Bernard, “Cell surface proteoglycan expression during maturation of human monocytes-derived dendritic cells and macrophages,” Clinical and Experimental Immunology, vol. 144, no. 3, pp. 485–493, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. C. J. Malavaki, A. D. Theocharis, F. N. Lamari et al., “Heparan sulfate: biological significance, tools for biochemical analysis and structural characterization,” Biomedical Chromatography, vol. 25, no. 1, pp. 11–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Olczyk, K. Komosińska-Vassev, K. Winsz-Szczotka et al., “Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing,” Journal of Zheijang University Science B, vol. 13, no. 11, pp. 932–941, 2012. View at Google Scholar
  33. T. A. Dechert, A. E. Ducale, S. I. Ward, and D. R. Yager, “Hyaluronan in human acute and chronic dermal wounds,” Wound Repair and Regeneration, vol. 14, no. 3, pp. 252–258, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. A. J. Busti, J. S. Hooper, C. J. Amaya, and S. Kazi, “Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing,” Pharmacotherapy, vol. 25, no. 11 I, pp. 1566–1591, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. J. M. Reinke and H. Sorg, “Wound repair and regeneration,” European Surgical Research, vol. 49, no. 1, pp. 35–43, 2012. View at Google Scholar
  36. J. M. Shah, E. Omar, D. R. Pai, and S. Sood, “Cellular events and biomarkers of wound healing,” Indian Journal of Plastic Surgery, vol. 45, no. 2, pp. 220–228, 2012. View at Publisher · View at Google Scholar
  37. Y. Wu and S. Chen, “Apoptotic cell: linkage of inflammation and wound healing,” Frontiers in Pharmacology, vol. 5, article 1, 2014. View at Publisher · View at Google Scholar
  38. G. C. Gurtner, S. Werner, Y. Barrandon, and M. T. Longaker, “Wound repair and regeneration,” Nature, vol. 453, no. 7193, pp. 314–321, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Hoffman, A. Harger, A. Lenkowski, U. Hedner, H. R. Roberts, and D. M. Monroe, “Cutaneous wound healing is impaired in hemophilia B,” Blood, vol. 108, no. 9, pp. 3053–3060, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. L. F. Brass, “Thrombin and platelet activation,” Chest, vol. 124, supplement 3, pp. 18S–25S, 2003. View at Google Scholar · View at Scopus
  41. R. Riessen, T. N. Wight, C. Pastore, C. Henley, and J. M. Isner, “Distribution of hyaluronan during extracellular matrix remodeling in human restenotic arteries and balloon-injured rat carotid arteries,” Circulation, vol. 93, no. 6, pp. 1141–1147, 1996. View at Google Scholar · View at Scopus
  42. N. Laurens, P. Koolwijk, and M. P. de Maat, “Fibrin structure and wound healing,” Journal of Thrombosis and Haemostasis, vol. 4, no. 5, pp. 932–939, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Blair and R. Flaumenhaft, “Platelet α-granules: basic biology and clinical correlates,” Blood Reviews, vol. 23, no. 4, pp. 177–189, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. H. S. Yang, J. Shin, S. H. Bhang et al., “Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma,” Experimental and Molecular Medicine, vol. 43, no. 11, pp. 622–629, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. T. J. Koh and L. A. DiPietro, “Inflammation and wound healing: the role of the macrophage,” Expert Reviews in Molecular Medicine, vol. 13, article e23, 12 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Howard, R. Asmis, K. Evans, and T. Mustoe, “Oxygen and wound care: a critical review of current therapeutic modalities and future direction,” Wound Repair and Regeneration, vol. 21, no. 4, pp. 503–511, 2013. View at Google Scholar
  47. P. Olczyk, P. Ramos, M. Biernas, K. Komosinska-Vassev, J. Stojko, and B. Pilawa, “Application of electron paramagnetic resonance spectroscopy to comparative examination of different groups of free radicals in thermal injuries treated with propolis and silver sulphadiazine,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 851940, 11 pages, 2013. View at Publisher · View at Google Scholar
  48. P. Olczyk, P. Ramos, M. Biernas, K. Komosinska-Vassev, J. Stojko, and B. Pilawa, “Microwave saturation of complex EPR spectra and free radicals of burnt skin treated with apitherapeutic agent,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 545201, 9 pages, 2013. View at Publisher · View at Google Scholar
  49. T. Lucas, A. Waisman, R. Ranjan et al., “Differential roles of macrophages in diverse phases of skin repair,” Journal of Immunology, vol. 184, no. 7, pp. 3964–3977, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. S. K. Brancato and J. E. Albina, “Wound macrophages as key regulators of repair: origin, phenotype, and function,” American Journal of Pathology, vol. 178, no. 1, pp. 19–25, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Woodfin, M.-B. Voisin, and S. Nourshargh, “Recent developments and complexities in neutrophil transmigration,” Current Opinion in Hematology, vol. 17, no. 1, pp. 9–17, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. K. R. Taylor, J. M. Trowbridge, J. A. Rudisill, C. C. Termeer, J. C. Simon, and R. L. Gallo, “Hyaluronan fragments stimulate endothelial recognition of injury through TLR4,” Journal of Biological Chemistry, vol. 279, no. 17, pp. 17079–17084, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Yoneda and J. R. Couchman, “Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans,” Matrix Biology, vol. 22, no. 1, pp. 25–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  54. M. B. Witte and A. Barbul, “Role of nitric oxide in wound repair,” American Journal of Surgery, vol. 183, no. 4, pp. 406–412, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. M. P. Rodero and K. Khosrotehrani, “Skin wound healing modulation by macrophages,” International Journal of Clinical and Experimental Pathology, vol. 3, no. 7, pp. 643–653, 2010. View at Google Scholar · View at Scopus
  56. B. M. Delavary, W. M. van der Veer, M. van Egmond, F. B. Niessen, and R. H. J. Beelen, “Macrophages in skin injury and repair,” Immunobiology, vol. 216, no. 7, pp. 753–762, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. S. A. Eming, T. Krieg, and J. M. Davidson, “Inflammation in wound repair: molecular and cellular mechanisms,” Journal of Investigative Dermatology, vol. 127, no. 3, pp. 514–525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  58. S. A. Eming, B. Brachvogel, T. Odorisio, and M. Koch, “Regulation of angiogenesis: wound healing as a model,” Progress in Histochemistry and Cytochemistry, vol. 42, no. 3, pp. 115–170, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. S. A. Eming, M. Hammerschmidt, T. Krieg, and A. Roers, “Interrelation of immunity and tissue repair or regeneration,” Seminars in Cell and Developmental Biology, vol. 20, no. 5, pp. 517–527, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. S. Willenborg, T. Lucas, G. van Loo et al., “CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair,” Blood, vol. 120, no. 3, pp. 623–625, 2012. View at Google Scholar
  61. J. M. Daley, S. K. Brancato, A. A. Thomay, J. S. Reichner, and J. E. Albina, “The phenotype of murine wound macrophages,” Journal of Leukocyte Biology, vol. 87, no. 1, pp. 59–67, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. V. S. Rajkumar, X. Shiwen, M. Bostrom et al., “Platelet-derived growth factor-β receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing,” American Journal of Pathology, vol. 169, no. 6, pp. 2254–2265, 2006. View at Publisher · View at Google Scholar · View at Scopus
  63. J. M. Shah, E. Omar, D. R. Pai, and S. Sood, “Cellular events and biomarkers of wound healing,” Indian Journal of Plastic Surgery, vol. 45, no. 2, pp. 220–228, 2012. View at Google Scholar
  64. J. M. Sorrell and A. I. Caplan, “Fibroblast heterogeneity: more than skin deep,” Journal of Cell Science, vol. 117, no. 5, pp. 667–675, 2004. View at Publisher · View at Google Scholar · View at Scopus
  65. B. Li and J. H.-C. Wang, “Fibroblasts and myofibroblasts in wound healing: force generation and measurement,” Journal of Tissue Viability, vol. 20, no. 4, pp. 108–120, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. B. Eckes, R. Nischt, and T. Krieg, “Cell-matrix interactions in dermal repair and scarring,” Fibrogenesis and Tissue Repair, vol. 3, no. 1, article 4, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. T. H. Barker, “The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine,” Biomaterials, vol. 32, no. 18, pp. 4211–4214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  68. G. Nowak and A. Olejek, “Biological and molecular aspects of wound healing,” Practical Gynecology, vol. 12, pp. 2–30, 2004. View at Google Scholar
  69. A. Nauta, G. C. Gurtner, and M. T. Longaker, “Wound healing and regenerative strategies,” Oral Diseases, vol. 17, no. 6, pp. 541–549, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. E. M. Koźma, K. Olczyk, A. Głowacki, and R. Korbut, “Wound repair,” Advances in Hygiene and Experimental Medicine, vol. 52, pp. 173–185, 1998. View at Google Scholar
  71. P.-J. Wipff, D. B. Rifkin, J.-J. Meister, and B. Hinz, “Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix,” Journal of Cell Biology, vol. 179, no. 6, pp. 1311–1323, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. J. J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, and R. A. Brown, “Myofibroblasts and mechano: regulation of connective tissue remodelling,” Nature Reviews Molecular Cell Biology, vol. 3, no. 5, pp. 349–363, 2002. View at Publisher · View at Google Scholar · View at Scopus
  73. B. Hinz, “Formation and function of the myofibroblast during tissue repair,” Journal of Investigative Dermatology, vol. 127, no. 3, pp. 526–537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. R. Gallo, Ch. Kim, R. Kokenyesi, N. S. Adzick, and M. Bernfield, “Syndecans-1 and -4 are induced during wound repair of neonatal but not fetal skin,” Journal of Investigative Dermatology, vol. 107, no. 5, pp. 676–683, 1996. View at Google Scholar · View at Scopus
  75. J. Li, Y.-P. Zhang, and R. S. Kirsner, “Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix,” Microscopy Research and Technique, vol. 60, no. 1, pp. 107–114, 2003. View at Publisher · View at Google Scholar · View at Scopus
  76. S. M. Bauer, R. J. Bauer, and O. C. Velazquez, “Angiogenesis, vasculogenesis, and induction of healing in chronic wounds,” Vascular and Endovascular Surgery, vol. 39, no. 4, pp. 293–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  77. F. Arnold and D. C. West, “Angiogenesis in wound healing,” Pharmacology and Therapeutics, vol. 52, no. 3, pp. 407–422, 1991. View at Publisher · View at Google Scholar · View at Scopus
  78. M. G. Tonnesen, X. Feng, and R. A. F. Clark, “Angiogenesis in wound healing,” Journal of Investigative Dermatology Symposium Proceedings, vol. 5, no. 1, pp. 40–46, 2000. View at Publisher · View at Google Scholar · View at Scopus
  79. M. Slevin, S. Kumar, and J. Gaffney, “Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses,” Journal of Biological Chemistry, vol. 277, no. 43, pp. 41046–41059, 2002. View at Publisher · View at Google Scholar · View at Scopus
  80. A. J. Day and G. D. Prestwich, “Hyaluronan-binding proteins: tying up the giant,” Journal of Biological Chemistry, vol. 277, no. 7, pp. 4585–4588, 2002. View at Publisher · View at Google Scholar · View at Scopus
  81. K. K. Sethi, I. V. Yannas, V. Mudera, M. Eastwood, C. McFarland, and R. A. Brown, “Evidence for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast-mediated collagen contraction,” Wound Repair and Regeneration, vol. 10, no. 6, pp. 397–408, 2002. View at Publisher · View at Google Scholar · View at Scopus
  82. M. R. Mariappan, E. A. Alas, J. G. Williams, and M. D. Prager, “Chitosan and chitosan sulfate have opposing effects on collagen-fibroblast interactions,” Wound Repair and Regeneration, vol. 7, no. 5, pp. 400–406, 1999. View at Google Scholar · View at Scopus
  83. R. M. Farahani and L. C. Kloth, “The hypothesis of “biophysical matrix contraction”: wound contraction revisited,” International Wound Journal, vol. 5, no. 3, pp. 477–482, 2008. View at Publisher · View at Google Scholar · View at Scopus
  84. V. Sarrazy, F. Billet, L. Micallef, B. Coulomb, and A. Desmoulière, “Mechanisms of pathological scarring: role of myofibroblasts and current developments,” Wound Repair and Regeneration, vol. 19, supplement 1, pp. S10–S15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  85. A. Desmoulière, C. Chaponnier, and G. Gabbiani, “Tissue repair, contraction, and the myofibroblast,” Wound Repair and Regeneration, vol. 13, no. 1, pp. 7–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  86. B. Nedelec, A. Ghahary, P. G. Scott, and E. E. Tredget, “Control of wound contraction: basic and clinical features,” Hand Clinics, vol. 16, no. 2, pp. 289–302, 2000. View at Google Scholar · View at Scopus
  87. N. Vedrenne, B. Coulomb, A. Danigo, F. Bonté, and A. Desmoulière, “The complex dialogue between (myo)fibroblasts and the extracellular matrix during skin repair processes and ageing,” Pathologie Biologie, vol. 60, no. 1, pp. 20–27, 2012. View at Publisher · View at Google Scholar · View at Scopus
  88. K. Kuwaba, M. Kobayashi, Y. Nomura, S. Irie, and Y.-I. Koyama, “Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps,” Biochemical Journal, vol. 358, no. 1, pp. 157–163, 2001. View at Publisher · View at Google Scholar · View at Scopus
  89. P. Olczyk, G. Wisowski, K. Komosinska-Vassev et al., “Propolis modifies collagen types I and III accumulation in the matrix of burnt tissue,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 423809, 10 pages, 2013. View at Publisher · View at Google Scholar
  90. K. R. Taylor and R. L. Gallo, “Glycosaminoglycans and their proteoglycans: host-associated molecular patterns for initiation and modulation of inflammation,” The FASEB Journal, vol. 20, no. 1, pp. 9–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
  91. P. V. Peplow, “Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds,” Thrombosis and Haemostasis, vol. 94, no. 1, pp. 4–16, 2005. View at Publisher · View at Google Scholar · View at Scopus
  92. R. L. Gallo, “Proteoglycans and cutaneous vascular defense and repair,” Journal of Investigative Dermatology Symposium Proceedings, vol. 5, no. 1, pp. 55–60, 2000. View at Publisher · View at Google Scholar · View at Scopus
  93. W. Y. J. Chen and G. Abatangelo, “Functions of hyaluronan in wound repair,” Wound Repair and Regeneration, vol. 7, no. 2, pp. 79–89, 1999. View at Publisher · View at Google Scholar · View at Scopus