SNP rs8099917 in Gene IL28B Might Be Associated with Risk of Chronic Infection by HCV but Not with Response to Treatment

Table 2

Association of SNPs rs12979860 and rs8099917 with sustained virologic response in individuals with chronic hepatitis C treated with PEG-IFN and RBV.

SNPs	Type of response		𝑁	OR (CI 95%)	𝑃^∗	𝑃^a,b
	SVR	Non-SVR + Non-ETR + NR
rs12979860
Genotypes
CC	08 (61.5)	05 (38.5)	13	4.00 (1.0004–0.0950)	0.0950	0.1454^a
CT	06 (30.0)	14 (70.0)	20	0.47 (0.1306–1.7020)	0.4033
TT	02 (25.0)	06 (75.0)	08	0.45 (0.0792–2.5848)	0.6153
Alleles
C	22 (46.8)	24 (53.2)	47	2.38 (0.9395–6.0461)	0.1055	0.1055^b
T	10 (27.8)	26 (72.2)	36
rs8099917
Genotypes
GG	01 (25.0)	03 (75.0)	04	0.49 (0.0463–5.1595)	0.9475	0.5908^a
GT	06 (33.3)	12 (66.7)	18	0.65 (0.1806–2.3393)	0.7351
TT	09 (47.4)	10 (52.6)	19	1.93 (0.5410–6.8755)	0.4859
Alleles
G	8 (30.8)	18 (59.2)	26	0.59 (0.2209–1.5897)	0.4232	0.4232^b
T	24 (42.9)	32 (57.1)	56

∗OR (CC  versus  CT  versus  TT). ^a𝐺-test; bchi-square test.
SVR: sustained virologic response; ETR: end-of-treatment response; NR: null response.