Ibuprofen Protects Ventilator-Induced Lung Injury by Downregulating Rho-Kinase Activity in Rats
Figure 1
(a) Lung wet-to-dry weight ratio, (b) total protein concentration, and (c) myeloperoxidase (MPO) activity in bronchoalveolar lavage fluid (BALF) in the control, high volume zero pressure (HVZP), HVZP + ibuprofen (Ibu) 15 mg/kg, and HVZP + ibuprofen 30 mg/kg groups. All rats were randomly divided into four groups: the control group () did not receive ventilation; the HVZP group () received 2 hours of ventilation at a tidal volume of 35 mL/kg, a respiratory rate of 25 breaths/minute, and an FiO2 of 0.21; the HVZP + ibuprofen 15 mg/kg group () received an intravenous injection of ibuprofen (15 mg/kg) 15 minutes before the HVZP ventilation; and the HVZP + ibuprofen 30 mg/kg group () received an intravenous injection of ibuprofen (30 mg/kg). , , and .
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