Ibuprofen Protects Ventilator-Induced Lung Injury by Downregulating Rho-Kinase Activity in Rats

Figure 1

(a) Lung wet-to-dry weight ratio, (b) total protein concentration, and (c) myeloperoxidase (MPO) activity in bronchoalveolar lavage fluid (BALF) in the control, high volume zero pressure (HVZP), HVZP + ibuprofen (Ibu) 15 mg/kg, and HVZP + ibuprofen 30 mg/kg groups. All rats were randomly divided into four groups: the control group (𝑛=7) did not receive ventilation; the HVZP group (𝑛=7) received 2 hours of ventilation at a tidal volume of 35 mL/kg, a respiratory rate of 25 breaths/minute, and an FiO₂ of 0.21; the HVZP + ibuprofen 15 mg/kg group (𝑛=7) received an intravenous injection of ibuprofen (15 mg/kg) 15 minutes before the HVZP ventilation; and the HVZP + ibuprofen 30 mg/kg group (𝑛=7) received an intravenous injection of ibuprofen (30 mg/kg). ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.

(a)

(b)

(c)