Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways

Figure 1

p53-induced miRNAs control cell cycle and cell survival. p53 directly induces many kinds of miRNAs, which repress cell-cycle regulators and/or antiapoptotic proteins and contribute to cell-cycle arrest and apoptosis. The miRNAs regulating apoptosis are shown in the top part of this figure, and the miRNAs regulating the cell cycle are at the bottom.