Genetic Networks Lead and Follow Tumor Development: MicroRNA Regulation of Cell Cycle and Apoptosis in the p53 Pathways

Table 1

Key microRNAs regulated by p53.

miRNA	Genomic location	Cancer type	Target	Phenotype	References
miR-34s	1p36 and 11q23	Colon cancer, neuroblastoma, pancreatic cancer, CLL,; NSCLC,; OSCC, breast cancer, bladder cancer, kidney cancer, melanoma	CDK4, CDK6, cyclin E2, E2F3, MYC; BCL-2	Cell-cycle arrest apoptosis	[14–16, 18, 51, 53, 54]
miR-107	10q23	Colon cancer, breast cancer	CDK6, P130	Cell-cycle arrest	[55–57]
miR-145	5q23	Colon cancer, breast cancer, MDS,; prostate cancer	MYC, E2F3, cyclin D2, CDK4, CDK6	Cell-cycle arrest	[58–61]
miR-192/215	1q41 and 11q13	Colon cancer, lung cancer, multiple myeloma, renal cancer	CDC7, MAD2L1	Cell-cycle arrest	[66–69]
miR-200c	12p13	Breast cancer, ovarian cancer	FAP-1	Apoptosis	[71, 81]
let-7	Multiple locations (11 copies)	Lung cancer, colon cancer, ovarian cancer, breast cancer, lymphoma	CDK6, CDC25A, cyclin D, CDC34, MYC, E2F1, E2F3	Cell-cycle arrest	[61, 83–90]
miR-15a/16-1	13q14	B-CLL,; pituitary adenomas, gastric cancer, NSCLC, prostate cancer, ovarian cancer, pancreatic cancer	CDK1, CDK2, CDK6, cyclin D1, D3, E1; BCL-2	Cell-cycle arrest apoptosis	[98–112]

CLL: chronic lymphocytic leukemia; NSCLC: non-small cell lung cancer; OSCC: oral squamous cell carcinoma; MDS: myelodysplastic syndromes; B-CLL: B-cell chronic lymphocytic leukemia.