| GPCRs | Tumor | Function | References |
| FPR | | | | FPR1 | Colorectal cancer | Invasion | [158] | Gastric cancer | Invasion | [159] | Glioblastoma | Growth, invasion, vasculogenesis, angiogenesis | [160–163] | FPR2 | Gastric cancer | Invasion | [159] | Ovarian cancer | Invasion | [164] | FPR3 | Gastric cancer | Invasion | [159] | PAFR | Breast cancer | Migration, proliferation, angiogenesis | [165] | Melanoma | Metastasis | [166] | Ovarian cancer | Proliferation, invasion | [167] | C5aR | Bile duct cancer, colorectal cancer | Invasion | [168] | Non-small-cell lung cancer | Metastasis | [169] | LTB4R | | | | BLT1 | Colorectal cancer | Proliferation | [170] | BLT2 | Bladder cancer | Metastasis, antiapoptosis | [171, 172] | Breast cancer | Metastasis | [173] | Pancreatic cancer | Growth, migration | [174, 175] | Prostate cancer | Antianoikis, antiapoptosis | [176, 177] | Ovarian cancer | Metastasis | [178] | CCR | | | | CCR1 | Breast cancer | Invasion | [179] | Glioma | Proliferation, tumorigenesis | [180] | Hepatocellular carcinoma | Migration, invasion | [181, 182] | Oral squamous cell carcinoma | Migration | [183] | Ovarian cancer | Invasion | [184] | CCR2 | Bladder cancer | Migration, invasion | [185] | Breast cancer | Migration, proliferation, antiapoptosis | [186] | Hepatocellular carcinoma | Migration, invasion | [181] | Multiple myeloma | Growth | [187] | Ovarian cancer | Invasion, adhesion, proliferation | [188, 189] | Prostate cancer | Proliferation, migration, invasion | [190, 191] | CCR3 | Lymphoma | Growth | [192] | Glioma | Proliferation, tumorigenesis | [180] | Oral squamous cell carcinoma | Migration, invasion | [183] | Ovarian cancer | Invasion, proliferation | [184, 189] | Renal cell carcinoma | Growth, dissemination | [193] | CCR4 | Breast cancer | Growth, metastasis, angiogenesis | [139, 194] | Colorectal cancer | Migration | [195] | Gastric cancer | Migration | [196] | Melanoma | Metastasis | [197] | Squamous cell carcinoma of the head and neck | Metastasis | [198] | CCR5 | Breast cancer | Proliferation, metastasis | [25, 199–202] | Colorectal cancer | Growth | [203] | Gastric cancer | Metastasis | [204] | Glioma | Proliferation, tumorigenesis | [180] | Hodgkin lymphoma | Growth, metastasis | [205] | Oral cancer | Migration | [206] | Ovarian cancer | Invasion, proliferation | [189] | CCR6 | Colorectal cancer | Proliferation, metastasis | [207, 208] | Endometrial adenocarcinoma | Proliferation | [27] | Hepatocellular carcinoma | Metastasis | [209, 210] | Non-small-cell lung cancer | Metastasis | [211] | Pancreatic cancer | Invasion | [212–214] | Squamous cell carcinoma of the head and neck | Metastasis | [215, 216] | CCR7 | Breast cancer | Metastasis, antianoikis | [217, 218] | Colorectal cancer | Metastasis | [219, 220] | Melanoma | Growth, metastasis, tumorigenesis | [221, 222] | Non-small-cell lung cancer | Proliferation, antiapoptosis, metastasis | [29, 223–226] | Oral squamous cell carcinoma | Metastasis | [227] | Pancreatic ductal adenocarcinoma | Metastasis | [228] | Prostate cancer | Metastasis | [229] | Squamous cell carcinoma of the head and neck | Proliferation, antiapoptosis, metastasis, adhesion | [230–236] | T cell lymphoma | Dissemination | [237] | CCR8 | Melanoma, breast cancer, leukemia | Metastasis | [32] | CCR9 | Breast cancer | Migration, invasion | [238] | Colorectal cancer | Inhibiting metastasis | [239] | Ovarian cancer | Migration, invasion | [240] | Pancreatic cancer | Proliferation, invasion | [34, 241] | Prostate cancer | Antiapoptosis | [242] | CCR10 | Melanoma | Growth, metastasis | [243, 244] | CXCR | | | | CXCR1 | Breast cancer | Stem cell self-renewal | [245] | Cervical carcinoma | Proliferation | [246] | Colorectal cancer | Metastasis, antiapoptosis, angiogenesis | [247] | Gastric cancer | Invasion | [248] | Glioblastoma | Growth, migration, invasion | [249, 250] | Melanoma | Growth, migration, invasion, angiogenesis, tumorigenesis | [251–253] | Prostate cancer | Growth, angiogenesis | [254] | Renal cell carcinoma | Growth, angiogenesis | [37] | Thyroid carcinoma | Metastasis | [255] | CXCR2 | Breast cancer | Migration, invasion, stem cell self-renewal | [245, 256, 257] | Cervical carcinoma | Proliferation | [246] | Colorectal cancer | Proliferation, migration, invasion, angiogenesis | [258–261] | Gastric cancer | Metastasis | [262, 263] | Glioblastoma | Growth, migration | [249, 264] | Melanoma | Growth, migration, invasion, angiogenesis, tumorigenesis | [251–253] | Nasopharyngeal carcinoma | Growth | [265] | Non-small-cell lung cancer | Growth, metastasis, angiogenesis | [266, 267] | Ovarian cancer | Growth, angiogenesis | [268] | Pancreatic cancer | Invasion, angiogenesis | [269] | Prostate cancer | Growth, angiogenesis | [254] | Renal cell carcinoma | Growth, angiogenesis | [37] | Thyroid carcinoma | Metastasis | [255] | CXCR3 | Breast cancer | Metastasis; inhibiting growth | [270–273] | Colorectal cancer | Metastasis | [274] | Glioma | Growth | [275, 276] | Lung adenocarcinoma | Metastasis | [226] | Melanoma | Migration | [277] | | Myeloma | Inhibiting/promoting proliferation and apoptosis | [43] | | Ovarian cancer | Growth, metastasis | [278] | | Prostate cancer | Metastasis | [279] | | Renal cell carcinoma | Growth, metastasis | [280, 281] | CXCR4 | At least 23 haematopoietic and solid cancers | Growth, metastasis, angiogenesis | [1, 44] | CXCR5 | Breast cancer | Metastasis | [282] | Colorectal cancer | Growth, migration | [283] | Neuroblastoma | Inhibiting/promoting metastasis | [45, 284] | Prostate cancer | Proliferation, invasion, migration, adhesion | [285–288] | CXCR6 | Colorectal cancer | Growth, migration, invasion | [289] | Hepatocellular carcinoma | Growth, metastases, angiogenesis | [3] | Melanoma | Stem cell self-renewal | [290] | Nasopharyngeal carcinoma | Metastasis | [291] | Pancreatic ductal adenocarcinoma | Invasion | [292] | Prostate cancer | Proliferation, metastasis | [293–295] | Renal cell carcinoma | Inhibiting migration | [296] | CXCR7 | Breast cancer | Inhibiting invasion; growth, angiogenesis | [297] | Cervical carcinoma | Growth, adhesion | [298] | Glioma | Growth, migration, sphere and tube formation | [49, 299] | Hepatocellular carcinoma | Growth, metastasis, angiogenesis | [300, 301] | Lymphoma | Growth, adhesion | [298] | Nasopharyngeal carcinoma | Metastasis | [291] | Neuroblastoma | Inhibiting growth; metastasis | [50, 302] | CX3CR | | | | CX3CR1 | Epithelial ovarian carcinoma | Proliferation, migration, adhesion | [303] | Glioma | Inhibiting invasion | [304] | Neuroblastoma | Migration | [305] | Pancreatic ductal adenocarcinoma | Migration | [306, 307] | Prostate cancer | Metastasis | [308–310] | Renal cell carcinoma | Metastasis | [311] | XCR | | | | XCR1 | Epithelial ovarian carcinoma | Proliferation, metastasis | [312] | Oral squamous cell carcinoma | Proliferation, migration, invasion | [313] |
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