Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells

Figure 11

The reactions of MCB, CDNB, and glutathione in a reaction catalysed by glutathione transferases. The MCB-GSH and the CDNB-GSH conjugates can both be effluxed by MRP proteins. Competition between MCB and CDNB, therefore, is both at GST-mediated catalysis as well as MRP-mediated efflux.