Alterations of the Myovesical Plexus of the Human Overactive Detrusor

Table 1

Semiquantitative analysis of intrafascicular N-cadherin and PGP9.5 expression in control and overactive detrusor.

	𝑛	Fascicle 1		Fascicle 2		Fascicle 3		Fascicle 4
		N-cad	PGP9.5	N-cad	PGP9.5	N-cad	PGP9.5	N-cad	PGP9.5
GSI	1	+	++	+	+	+	++	+	++
		+	++	+	++	+	++	+	+++
	2	++	++	+	++	++	−	Error	Error
		+	−	+	++	+	+	+	++
	3	+	++	+	++	+	+	+	+
		+	++	+	+	+	++	+	+++
	4	+	+	++	++	++	−	+	+
		++	++	+	++	+	+	+	++
	5	+	++	+	+	+	++	+	++
		+	++	+	++	+	++	+	+
NDO	1	++	+	++	+	++	+	Error	Error
		+	+	++	++	+++	−	++	−
	2	+	+	++	+	+	+	++	+
		+	−	+	−	++	+	++	−
	3	+	+	++	++	+	+	++	+
		++	+	+	+	+	−	++	−
	4	++	+	Error	Error	+	+	Error	Error
		+	−	++	+	++	−	+++	−
	5	++	+	++	+	+	++	+	++
		+	−	+++	−	+	+	++	+
	6	+	+	Error	Error	++	+	+	+
		+	−	++	+	+	−	+++	−
BDO	1	+	+	++	+	+	+	++	+
		++	+	+	−	+++	−	++	−
	2	+	+	+	+++	+	++	++	+
		++	−	++	+	++	+	++	+
	3	++	+	++	+	++	+	Error	Error
		++	−	+	+	++	−	++	−
	4	+	+++	Error	Error	++	+	+	+
		+++	−	+++	−	++	−	++	−
	5	+	+	+	++	+	+	+	++
		+	++	+++	−	+++	−	+	++
	6	+	+	++	++	+	+	+++	+
		++	+	++	++	+	+++	+	++
IDO	1	++	+	+	+	+++	+	+	+
		+++	−	++	−	+++	−	++	++
	2	Error	Error	++	+	Error	Error	++	+
		++	+	+	+	+++	−	++	−
	3	+	++	+	++	++	+	++	+
		+	−	++	+	+	++	++	−
	4	+++	+	++	+	+++	+	Error	Error
		+	+	+++	−	++	−	++	−
	5	++	+	++	+	Error	Error	+	+
		++	++	++	+	++	−	+	++
	6	++	+	+	+++	+	+++	+++	−
		+	++	+++	−	+++	−	+	++

Smooth muscle fascicles were semiquantitatively analysed for intrafascicular expression of N-cadherin and PGP9.5, and graded as follows: features not present in any photographs, − (no expression); present >0–1/3, + (low expression); present in 1/3–2/3, ++ (intermediate expression); present in 2/3–entire fascicle, +++ (high expression). BDO: DO due to bladder outlet obstruction; NDO: neurogenic DO; IDO: idiopathic DO; GSI: genuin stress incontinence = control bladder. Note the heterogeneity of N-cadherin and PGP9.5 expression profile throughout the control and overactive specimens. In some cases, fatty tissue texture complicated specimen processing. Therefore, we were unable to study some fascicles (see: error).