Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions
Figure 2
After stimulation with angiogenic factors of a quiescent vessel (a), the degradation of the basement membrane, pericyte detachment, and loosening of endothelial cell junctions occur (b). Endothelial cells begin to proliferate, migrate, and take part in formation of an immature capillary structure and deposition of a new complex basement membrane (c). Finally, pericytes are recruited thereby providing stabilization for the new vessel (d).
