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BioMed Research International
Volume 2014, Article ID 758672, 13 pages
Research Article

Effect of Duplicate Genes on Mouse Genetic Robustness: An Update

1State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China
2Department of Genetics, Development & Cell Biology, Iowa State University, Ames, IA 50010, USA

Received 15 May 2014; Revised 15 June 2014; Accepted 16 June 2014; Published 10 July 2014

Academic Editor: Leng Han

Copyright © 2014 Zhixi Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: The effect of sequence conservation on the relationship between PE and duplicattion age. The dN/dS ration of mouse-rat one-to-one orthologous gene pairs was used as gene evolutionary conservation measurement. (a) Relationship between PE in singletons and the evolutionary conservation of the gene, measured by the ratio of the nonsynonymous (dN) to synonymous (dS) nucleotide distances between the target gene and its rat ortholog. (b) Mean dN/dSdS ratio for each age bin of duplicates. (c) PE in each age bin of duplicates—PE (dup, t) and that of singletons with the same dN/dS ratio—PE *(t). (d) Ratio of PE (dup, t) and PE *(t) in each age bin of duplicates.

  1. Supplementary Material