Biodegradable Polyphosphazene Biomaterials for Tissue Engineering and Delivery of Therapeutics

Figure 4

In vivo degradation process and in vivo localization of poly(organophosphazene)-doxorubicin (DOX) conjugate. Biodegradation as a time-dependent mass loss of intratumorally injected polymer-DOX conjugate (a). Time-dependent fluorescence image of intratumorally injected DOX solution (30 mg/kg) (b). Time-dependent fluorescence image of intratumorally injected poly(organophosphazene)-DOX conjugate hydrogel (100 mL, equivalent to 22.3 mg/kg of DOX) (c). Reprinted from [51] with permission from Elsevier.