High-Throughput Functional Screening of Steroid Substrates with Wild-Type and Chimeric P450 Enzymes

Figure 6

Human CYP1A1 shown in grey-blue ribbon structure (pdb entry 4i8v) highlighting sequence segment A (colored hot pink) and the heme (colored red). The two panels represent the structure rotated horizontally by 180° horizontally, with the I-helix viewed through its axis.