764981.fig.003a
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764981.fig.003b
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764981.fig.003c
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Figure 3: Exogenous HGF could also trigger sorafenib resistance in Huh7. (a) HGF of indicated concentration was administrated 2 h before sorafenib administration. HGF of 20 ng/mL rescued Huh7 from cell death. (b) DAPI staining was adopted for the manifestation of cell death. HGF of 20 ng/mL decreased sorafenib-induced cell death. (c) Crizotinib reversed HGF-induced cell survival. Crizotinib activated the cleavage of PARP and caspase-9 ( HGF 10 ng/mL versus control; sora: sorafenib).