BioMed Research International

BioMed Research International / 2014 / Article

Letter to the Editor | Open Access

Volume 2014 |Article ID 767538 |

Girish Chandra Bhatt, Tanya Sharma, "Comment on “Clinical Profile and Outcome of Japanese Encephalitis in Children Admitted with Acute Encephalitis Syndrome”", BioMed Research International, vol. 2014, Article ID 767538, 1 page, 2014.

Comment on “Clinical Profile and Outcome of Japanese Encephalitis in Children Admitted with Acute Encephalitis Syndrome”

Academic Editor: Edouard Cantin
Received23 Jul 2014
Accepted19 Aug 2014
Published27 Aug 2014

We read with great interest the article by Kakoti et al. [1] and have the following comments to offer.

Out of 223 hospitalized acute encephalitis syndrome patients, 30% (67) were diagnosed as confirmed Japanese encephalitis (JE). In the recent studies enteroviruses (EVs) are being identified as one of the common causes of encephalitis in children worldwide [2, 3]. Various studies from India, Kuwait, and European countries report the prevalence of EV in encephalitis cases to be as high as 21-22% in encephalitis endemic area. Though the authors have tested samples for other flaviviruses such as dengue and West Nile viruses, it is surprising that these samples were not tested for the commoner enteroviruses.

Secondly, authors have nicely outlined the clinicodemographic profile of JE patients. However, it is surprising to find that the recently reported nonneurological manifestations of JE are lacking in the paper. Hepatomegaly, splenomegaly, deranged liver function tests, deranged renal function tests, thrombocytopenia, and so forth have been reported in JE patients [4, 5]. Some authors have suggested a possible change in virulence of JE virus or strain variation over time, developing properties similar to dengue like flaviviruses, responsible for these manifestations [5].

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.


  1. G. Kakoti, P. Dutta, B. R. Das, J. Borah, and J. Mahanta, “Clinical profile and outcome of Japanese Encephalitis in children admitted with acute encephalitis syndrome,” BioMed Research International, vol. 2013, Article ID 152656, 5 pages, 2013. View at: Publisher Site | Google Scholar
  2. A. Dalwai, S. Ahmad, A. Pacsa, and W. Al-Nakib, “Echovirus type 9 is an important cause of viral encephalitis among infants and young children in Kuwait,” Journal of Clinical Virology, vol. 44, no. 1, pp. 48–51, 2009. View at: Publisher Site | Google Scholar
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  4. G. C. Bhatt, V. P. Bondre, G. N. Sapkal et al., “Changing clinico-laboratory profile of encephalitis patients in the eastern Uttar Pradesh region of India,” Tropical Doctor, vol. 42, no. 2, pp. 106–108, 2012. View at: Publisher Site | Google Scholar
  5. R. Kumar, P. Tripathi, S. Singh, and G. Bannerji, “Clinical features in children hospitalized during the 2005 epidemic of Japanese encephalitis in Uttar Pradesh, India,” Clinical Infectious Diseases, vol. 15, no. 43, pp. 123–131, 2006. View at: Google Scholar

Copyright © 2014 Girish Chandra Bhatt and Tanya Sharma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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