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BioMed Research International
Volume 2014 (2014), Article ID 768291, 6 pages
Research Article

Conspicuity of Peripheral Zone Prostate Cancer on Computed Diffusion-Weighted Imaging: Comparison of cDWI1500, cDWI2000, and cDWI3000

1Department of Radiology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey
2Department of Biomedical Engineering, Yeditepe University, Atasehir, 34755 Istanbul, Turkey
3School of Medicine, Koç University, Topkapı, 34104 Istanbul, Turkey
4Department of Urology, VKF American Hospital, Nisantası, 34365 Istanbul, Turkey
5Department of Pathology, School of Medicine, Acibadem University, Atasehir, 34752 Istanbul, Turkey
6Department of Biomedical Engineering, Namık Kemal University, Merkez, 59000 Tekirdağ, Turkey

Received 12 July 2014; Accepted 14 October 2014; Published 1 December 2014

Academic Editor: Barıs Turkbey

Copyright © 2014 Metin Vural et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction and Objective. Disadvantages associated with direct high b-value measurements may be avoided with use of computed diffusion-weighted imaging (cDWI). The purpose of this study is to assess the diagnostic performance of cDWI image sets calculated for high b-values of 1500, 2000, and 3000 s/mm2. Materials and Methods. Twenty-eight patients who underwent multiparametric MRI of the prostate and radical prostatectomy consecutively were enrolled in this retrospective study. Using a software developed at our institute, cDWI1500, cDWI2000, and cDWI3000 image sets were generated by fitting a monoexponential model. Index lesions on cDWI image sets were scored by two radiologists in consensus considering lesion conspicuity, suppression of background prostate tissue, distortion, image set preferability, and contrast ratio measurements were performed. Results. Lesion detection rates are the same for computed b-values of 2000 and 3000 s/mm2 and are better than b-values of 1500 s/mm2. Best lesion conspicuity and best background prostate tissue suppression are provided by cDWI3000 image set. cDWI2000 image set provides the best zonal anatomical delineation and less distortion and was chosen as the most preferred image set. Average contrast ratio measured on these image sets shows almost a linear relation with the b-values. Conclusion. cDWI2000 image set with similar conspicuity and the same lesion detection rate, but better zonal anatomical delineation, and less distortion, was chosen as the preferable image set.